BEST1

Gene Name		bestrophin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Chloride Channel Complex
	Molecular Function	Chloride Channel Activity
	Biological Process	Chloride Transport Visual Perception Transepithelial Chloride Transport Ion Transmembrane Transport Detection Of Light Stimulus Involved In Visual Perception Regulation Of Calcium Ion Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Ion channel transport Stimuli-sensing channels Orphan transporters
Drugs
Diseases
GWAS		Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-protein Interactions		2 interactors: PPP2CA PPP2R5A
Entrez ID		7439
HPRD ID		01094
Ensembl ID		ENSG00000167995
Uniprot IDs		B7Z1N8 B7Z375 O76090
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Mitotic Nuclear Envelope Reassembly Protein Heterotrimerization Nuclear Envelope Reassembly Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Inactivation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Protein Trimerization Negative Regulation Of Stem Cell Differentiation Regulation Of Phosphorylation Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Dephosphorylation Regulation Of Protein Localization To Plasma Membrane Regulation Of Epithelial To Mesenchymal Transition Regulation Of Lipid Kinase Activity Nuclear Envelope Organization Negative Regulation Of Lipid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of MAP Kinase Activity Regulation Of JAK-STAT Cascade Ceramide Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Regulation Of Receptor Activity Nucleus Organization Regulation Of Catalytic Activity Regulation Of DNA Replication Regulation Of Dephosphorylation Protein Heterooligomerization Negative Regulation Of Protein Serine/threonine Kinase Activity Second-messenger-mediated Signaling
Tagcloud ?		accumulate basolateral bestrophin ca centrifugation cl clarify compartment conducting counterion cytosolic degenerations endogenously helps influx knocked macular mandatory operated orai pigment porcine retinal rpe serca store stored stores vitelliforme