UQCRFS1 and SOX5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		UQCRFS1	SOX5
Gene Name		ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	SRY (sex determining region Y)-box 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III	Nuclear Transcription Factor Complex
	Molecular Function	Ubiquinol-cytochrome-c Reductase Activity Protein Complex Binding Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Response To Hormone Respiratory Electron Transport Chain Response To Drug Cellular Metabolic Process Small Molecule Metabolic Process Response To Antibiotic Hydrogen Ion Transmembrane Transport	In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Central Nervous System Neuron Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Oligodendrocyte Differentiation Cartilage Development Regulation Of Timing Of Neuron Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS			AIDS ( 19754311) Non-obstructive azoospermia ( 22197933) PR interval ( 20062060) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		3 interactors: CYC1 RELB SOX5	26 interactors: AES APP ARID5A CBX8 CDC23 CDC25A CDK6 CRX FAM46B FTH1 KAT5 KIFC3 LMO1 LMO2 MED27 MORN3 PRR20A RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TTC1 UQCRFS1 ZNF581
Entrez ID		7386	6660
HPRD ID		01874	18086
Ensembl ID			ENSG00000134532
Uniprot IDs		P47985	P35711 T2CYZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Timing Of Neuron Differentiation Regulation Of Mesenchymal Stem Cell Differentiation Response To Organic Substance T-helper 1 Cell Differentiation Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation T-helper 1 Type Immune Response T-helper Cell Differentiation Cellular Response To Osmotic Stress Positive Regulation Of Chondrocyte Differentiation Transcription From RNA Polymerase II Promoter Dendritic Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation NIK/NF-kappaB Signaling CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cartilage Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Stem Cell Differentiation Response To Glucagon I-kappaB Kinase/NF-kappaB Signaling Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Negative Regulation Of Gene Expression Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Oligodendrocyte Differentiation Circadian Regulation Of Gene Expression Response To Osmotic Stress Regulation Of Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Respiratory Electron Transport Chain Myeloid Leukocyte Differentiation Electron Transport Chain Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Osteoblast Fate Commitment Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cartilage Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process BMP Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Connective Tissue Development Transcription From RNA Polymerase II Promoter Metabolic Process Skeletal System Development Negative Regulation Of Biosynthetic Process Organ Development Cellular Response To BMP Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development
Tagcloud ?			aberrantly abrogated alcian atdc5 blue box chondrocyte chondrogenesis chondrogenic clonal delayed determining differentiating diminish drastic evidenced fate hypertrophic l lineage mobility osteoarthritic overexpressing progress proteoglycan retroviral runx2 unaltered
Tagcloud (Difference) ?			aberrantly abrogated alcian atdc5 blue box chondrocyte chondrogenesis chondrogenic clonal delayed determining differentiating diminish drastic evidenced fate hypertrophic l lineage mobility osteoarthritic overexpressing progress proteoglycan retroviral runx2 unaltered
Tagcloud (Intersection) ?