UMOD and LTA

Number of citations of the paper that reports this interaction (PMID 8323280)
2

Data Source:
HPRD (in vitro)

		UMOD	LTA
Gene Name		uromodulin	lymphotoxin alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Extracellular Space Golgi Apparatus Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Cytoplasmic Vesicle Membrane Raft Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Extracellular Space Membrane
	Molecular Function	Calcium Ion Binding IgG Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Cellular Defense Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Excretion Negative Regulation Of Cell Proliferation Response To Organic Substance Chemical Homeostasis Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Neutrophil Migration Regulation Of Ion Homeostasis	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation
Pathways
Drugs			Etanercept
Diseases
GWAS		Chronic kidney disease ( 20383146) Chronic kidney disease and serum creatinine levels ( 20686651) Femoral neck bone geometry ( 22087292) Hypertension ( 21082022) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)	Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		2 interactors: LTA MMP8	8 interactors: LGALS2 LTB LTBR TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD
Entrez ID		7369	4049
HPRD ID		11771	01084
Ensembl ID		ENSG00000169344	ENSG00000226979
Uniprot IDs		E9PEA4 P07911	P01374 Q5STV3
PDB IDs			1TNR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Positive Regulation Of Glial Cell Proliferation Lymph Node Development Positive Regulation Of Humoral Immune Response Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Fibroblast Proliferation Endodermal Cell Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Positive Regulation Of Gliogenesis Endoderm Formation Collagen Catabolic Process Defense Response To Gram-positive Bacterium Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Regulation Of Interferon-gamma Production Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Regulation Of Fibroblast Proliferation Regulation Of Gliogenesis Formation Of Primary Germ Layer Positive Regulation Of Adaptive Immune Response Gastrulation Defense Response To Bacterium Regulation Of Adaptive Immune Response	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Response To Cytokine Programmed Cell Death Positive Regulation Of Cytokine Production Immune System Process Cell Death Death Cellular Response To Mechanical Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Bacterium Defense Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Viral Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Metanephric Thick Ascending Limb Development Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Other Organism Response To Biotic Stimulus Response To External Stimulus Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Metanephric Ascending Thin Limb Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway Defense Response To Bacterium Positive Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Metanephric Distal Tubule Development Cellular Response To Stimulus Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		ascending autosomal c217g carrying concentrate delta0 delta2 deltadiast deltasyst deprivation desmopressin diuretic exaggerated fall furosemide headache intense maximally mmhg osmolality proband sib siblings sister thick tubular tubulointerstitial unaffected uromodulin	acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan
Tagcloud (Difference) ?		ascending autosomal c217g carrying concentrate delta0 delta2 deltadiast deltasyst deprivation desmopressin diuretic exaggerated fall furosemide headache intense maximally mmhg osmolality proband sib siblings sister thick tubular tubulointerstitial unaffected uromodulin	acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan
Tagcloud (Intersection) ?