UMOD and MMP8

Number of citations of the paper that reports this interaction (PMID 8397318)
4

Data Source:
HPRD (in vitro)

		UMOD	MMP8
Gene Name		uromodulin	matrix metallopeptidase 8 (neutrophil collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Extracellular Space Golgi Apparatus Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Cytoplasmic Vesicle Membrane Raft Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Calcium Ion Binding IgG Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Cellular Defense Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Excretion Negative Regulation Of Cell Proliferation Response To Organic Substance Chemical Homeostasis Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Neutrophil Migration Regulation Of Ion Homeostasis	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs			Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione Glycinamid Batimastat N-{2-[(4\'-CYANO-1,1\'-BIPHENYL-4-YL)OXY]ETHYL}-N\'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID (1R)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Chronic kidney disease ( 20383146) Chronic kidney disease and serum creatinine levels ( 20686651) Femoral neck bone geometry ( 22087292) Hypertension ( 21082022) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)	Prostate cancer ( 23535732)
Protein-Protein Interactions		2 interactors: LTA MMP8	7 interactors: ACAN BCAN CCL2 TFPI TIMP2 UBC UMOD
Entrez ID		7369	4317
HPRD ID		11771	00385
Ensembl ID		ENSG00000169344	ENSG00000118113
Uniprot IDs		E9PEA4 P07911	P22894
PDB IDs			1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Positive Regulation Of Glial Cell Proliferation Lymph Node Development Positive Regulation Of Humoral Immune Response Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Fibroblast Proliferation Endodermal Cell Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Positive Regulation Of Gliogenesis Endoderm Formation Collagen Catabolic Process Defense Response To Gram-positive Bacterium Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Regulation Of Interferon-gamma Production Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Regulation Of Fibroblast Proliferation Regulation Of Gliogenesis Formation Of Primary Germ Layer Positive Regulation Of Adaptive Immune Response Gastrulation Defense Response To Bacterium Regulation Of Adaptive Immune Response	Extracellular Matrix Disassembly Pathogenesis Neutrophil Migration Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Response To Vitamin B3 Helper T Cell Extravasation Negative Regulation Of Natural Killer Cell Chemotaxis Cellular Response To High Density Lipoprotein Particle Stimulus Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Metanephric Thick Ascending Limb Development Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Response To High Density Lipoprotein Particle Negative Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Metanephric Ascending Thin Limb Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Viral Life Cycle Regulation Of Cellular Protein Metabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Blood Coagulation, Extrinsic Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Mitotic Cell Cycle Leukocyte Migration MAPK Cascade Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Central Nervous System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Astrocyte Cell Migration Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of Apoptotic Cell Clearance
Tagcloud ?		ascending autosomal c217g carrying concentrate delta0 delta2 deltadiast deltasyst deprivation desmopressin diuretic exaggerated fall furosemide headache intense maximally mmhg osmolality proband sib siblings sister thick tubular tubulointerstitial unaffected uromodulin	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Difference) ?		ascending autosomal c217g carrying concentrate delta0 delta2 deltadiast deltasyst deprivation desmopressin diuretic exaggerated fall furosemide headache intense maximally mmhg osmolality proband sib siblings sister thick tubular tubulointerstitial unaffected uromodulin	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Intersection) ?