UMOD

Gene Name		uromodulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Extracellular Space Golgi Apparatus Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Cytoplasmic Vesicle Membrane Raft Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Calcium Ion Binding IgG Binding
	Biological Process	Cellular Defense Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Excretion Negative Regulation Of Cell Proliferation Response To Organic Substance Chemical Homeostasis Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Neutrophil Migration Regulation Of Ion Homeostasis
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Chronic kidney disease and serum creatinine levels ( 20686651) Femoral neck bone geometry ( 22087292) Hypertension ( 21082022) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)
Protein-protein Interactions		2 interactors: LTA MMP8
Entrez ID		7369
HPRD ID		11771
Ensembl ID		ENSG00000169344
Uniprot IDs		E9PEA4 P07911
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Positive Regulation Of Glial Cell Proliferation Lymph Node Development Positive Regulation Of Humoral Immune Response Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Fibroblast Proliferation Endodermal Cell Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Positive Regulation Of Gliogenesis Endoderm Formation Collagen Catabolic Process Defense Response To Gram-positive Bacterium Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Regulation Of Interferon-gamma Production Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Regulation Of Fibroblast Proliferation Regulation Of Gliogenesis Formation Of Primary Germ Layer Positive Regulation Of Adaptive Immune Response Gastrulation Defense Response To Bacterium Regulation Of Adaptive Immune Response
Tagcloud ?		ascending autosomal c217g carrying concentrate delta0 delta2 deltadiast deltasyst deprivation desmopressin diuretic exaggerated fall furosemide headache intense maximally mmhg osmolality proband sib siblings sister thick tubular tubulointerstitial unaffected uromodulin