C7 and CLU

Number of citations of the paper that reports this interaction (PMID 8345200)
14

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		C7	CLU
Gene Name		complement component 7	clusterin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function		Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Cellular Sodium Ion Homeostasis Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		3 interactors: C5 CLU PLG	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		730	1191
HPRD ID		01957	01706
Ensembl ID		ENSG00000112936	ENSG00000120885
Uniprot IDs		P10643 Q05CI3	P10909
PDB IDs		2WCY
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Neurofibrillary Tangle Assembly Leukocyte Migration Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Mononuclear Cell Migration Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Central Nervous System Myelin Maintenance Positive Regulation Of Fibrinolysis Regulation Of Tau-protein Kinase Activity Negative Regulation Of Dopamine Secretion Exocytosis Negative Regulation Of Protein Homooligomerization Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Norepinephrine Secretion Blood Coagulation Hemostasis Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Positive Regulation Of Protein Kinase Activity Positive Regulation Of Chemokine Secretion Negative Regulation Of Beta-amyloid Formation Negative Regulation Of Fibrinolysis Positive Regulation Of Kinase Activity Secretion By Cell In Utero Embryonic Development Complement Activation, Alternative Pathway Regulation Of Cytokine Production Regulation Of Norepinephrine Secretion Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Regulation Of Fibrinolysis Positive Regulation Of Transferase Activity	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		111in 5f10 accumulation alpha4 antihuman coadministration cytokine dm eosinophil eosinophils greatly hp2 igg inducer integrin integrins intradermal intravenous maximal moab mol numerous paf slowly tnfalpha tnfr totally uk vcam	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?		111in 5f10 accumulation alpha4 antihuman coadministration cytokine dm eosinophil eosinophils greatly hp2 igg inducer integrin integrins intradermal intravenous maximal moab mol numerous paf slowly tnfalpha tnfr totally uk vcam	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Intersection) ?