C7

Name	complement C7
Structure
Novel Interactors	1 novel interactors: ATXN1
Interactors	4 interactors: C5 CFTR CLU PLG
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways	Terminal pathway of complement Regulation of Complement cascade
Diseases	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS	Clozapine-induced cytotoxicity ( 25656473 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 )
Entrez ID	730
HPRD ID	01957
Ensembl ID	ENSG00000112936
Uniprot IDs	P10643 Q05CI3
PDB IDs	2WCY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
GO Terms Enriched among Interactors ?	Protein-folding Chaperone Binding Regulation Of Multicellular Organismal Process Signaling Receptor Binding Complement Activation Complement Activation, Classical Pathway Cholesterol Transport Platelet Alpha Granule Lumen Sterol Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Receptor Ligand Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Anion Channel Activity Cell Surface Positive Regulation Of Neurofibrillary Tangle Assembly Blood Microparticle Protein-containing Complex Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Enamel Mineralization Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis POZ Domain Binding Transepithelial Water Transport Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Leukocyte Migration Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Protein Import Regulation Of Neurofibrillary Tangle Assembly Humoral Immune Response Bicarbonate Transmembrane Transporter Activity