PRR20D and TIAL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRR20D	TIAL1
Description		proline rich 20D	TIA1 cytotoxic granule associated RNA binding protein like 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Cytolytic Granule
	Molecular Function	Protein Binding Identical Protein Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Protein-RNA Adaptor Activity
	Biological Process		Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			FGFR2 alternative splicing
Drugs
Diseases
GWAS		Smoking initiation ( 33082346)	Depressive symptoms (stressful life events interaction) ( 27529621) Monocyte percentage of white cells ( 32888494) Parkinson's disease ( 27182965) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539)
Interacting Genes		89 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NCK2 NFYC NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU2F1 POU6F2 PRR20A PRR20B PRR20C PRR20E PRR34 PRR35 PTTG2 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SH3RF1 SIAH1 SMAP1 SNRPB SNRPC SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF683	42 interacting genes: AKAP8L AOC1 BPIFA1 C10orf55 CAMK2A CEBPA CELF4 CREBBP DAZAP2 FAM168A FAM168B FUBP1 GRINA INCA1 KLF1 KRT31 KRTAP8-1 MAGED1 MAPK1 MAPK1IP1L MBNL2 MIR106A MIR106B MIR145 MIR199A1 MIR20A MIR29A MIR29C MIR34A MIR9-2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBPMS2 SMN1 SMN2 SNRPA VPS37C
Entrez ID		729246	7073
HPRD ID		19670	04563
Ensembl ID		ENSG00000227151	ENSG00000151923
Uniprot IDs		P86478 P86479 P86480 P86481 P86496	Q01085 Q49AS9
PDB IDs			1X4G 2CQI 2DH7
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Splicing Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MRNA Splicing, Via Spliceosome Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Myoblast Fate Commitment Nucleoplasm Regulation Of MRNA Metabolic Process MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Axis Specification U1 SnRNP Binding RNA Splicing	MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Extracellular Vesicle Post-transcriptional Regulation Of Gene Expression Regulation Of Angiogenesis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of BMP Signaling Pathway RNA Splicing Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction MRNA Destabilization Regulation Of MRNA Stability RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration
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