CDK11A and EIF3F

Number of citations of the paper that reports this interaction (PMID 12446680)
21

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CDK11A	EIF3F
Gene Name		cyclin-dependent kinase 11A	eukaryotic translation initiation factor 3, subunit F
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Regulation Of MRNA Processing Regulation Of Cell Cycle	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Proteolysis Gene Expression Protein Deubiquitination Cellular Protein Metabolic Process
Pathways		G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		6 interactors: B4GALT1 CCNL1 EIF3F GADD45A PIN1 SKIV2L	17 interactors: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MTOR PTN SHBG SMAD9 UBC
Entrez ID		728642	8665
HPRD ID			04887
Ensembl ID		ENSG00000008128	ENSG00000175390
Uniprot IDs		Q4VBY6 Q5QPR3 Q9UQ88	B4DEW9 O00303
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cellular Protein Metabolic Process Lactose Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Disaccharide Metabolic Process Regulation Of Protein Phosphorylation Penetration Of Zona Pellucida Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Activation Of MAPKKK Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of P38MAPK Cascade Regulation Of Acrosome Reaction Regulation Of Phosphorylation Cell Cycle DNA Unwinding Involved In DNA Replication Development Of Secondary Sexual Characteristics Regulation Of P38MAPK Cascade Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Oligosaccharide Biosynthetic Process	Positive Regulation Of Cellular Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Learning Or Memory Positive Regulation Of Macromolecule Biosynthetic Process Cognition Positive Regulation Of Gene Expression Response To Abiotic Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Learning Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cell Growth Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Transcription, DNA-templated Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Adult Behavior Regulation Of RNA Biosynthetic Process Single-organism Behavior Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Processing Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Phosphorylation Behavior Response To Growth Factor Regulation Of Carbohydrate Utilization Primary Spermatocyte Growth Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Translation Visual Learning Visual Behavior Response To Organic Substance Response To Hypoxia
Tagcloud ?			4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation
Tagcloud (Difference) ?			4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation
Tagcloud (Intersection) ?