LINC00460 and ELAVL1

Number of citations of the paper that reports this interaction (PubMedID 36513874)
36

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		LINC00460	ELAVL1
Description		long intergenic non-protein coding RNA 460	ELAV like RNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component		P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function		Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding
	Biological Process		LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways			HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Homeostasis model assessment of insulin resistance ( 30327367) Homeostasis model assessment of insulin resistance in more-fat diet ( 30327367) Intelligence ( 28530673)
Interacting Genes		2 interacting genes: ELAVL1 USP10	44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA
Entrez ID		728192	1994
HPRD ID			16025
Ensembl ID		ENSG00000233532	ENSG00000066044
Uniprot IDs			Q15717
PDB IDs			3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagosome Size Regulation Of Autophagosome Size LncRNA-mediated Post-transcriptional Gene Silencing Regulation Of Autophagy Negative Regulation Of Stress Granule Assembly Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Superoxide Anion Generation 3'-UTR-mediated MRNA Stabilization LncRNA Binding MRNA 3'-UTR AU-rich Region Binding Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Sarcoplasm Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Translesion Synthesis Molecular Function Inhibitor Activity Regulation Of Stress Granule Assembly Postreplication Repair Rescue Of Stalled Ribosome MiRNA Binding DNA Synthesis Involved In DNA Repair Ribosome Disassembly DNA Damage Response, Signal Transduction By P53 Class Mediator Intermediate Filament Cytoskeleton Cellular Response To Interleukin-1 Protein Monoubiquitination Positive Regulation Of Reactive Oxygen Species Metabolic Process MRNA Stabilization RNA Binding Translational Elongation Cysteine-type Endopeptidase Activity Double-stranded RNA Binding Regulation Of Stem Cell Population Maintenance P53 Binding Negative Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of RNA Catabolic Process Autophagosome Organization RNA Stabilization P-body Negative Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Negative Regulation Of Canonical NF-kappaB Signal Transduction DNA Biosynthetic Process	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity
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