TTF1 and WHRN

		TTF1	WHRN
Description		transcription termination factor 1	whirlin
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Cilium Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Bundle Stereocilium Tip Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Chromatin Remodeling DNA-templated Transcription Termination Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Establishment Of Localization In Cell Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression Surfactant metabolism RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Transcription Termination	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Benign hereditary chorea	Deafness, autosomal recessive Usher syndrome (US)
GWAS
Interacting Genes		6 interacting genes: BAZ2A CAVIN1 KAT2B NFATC3 SMAD1 SMAD7	17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN
Entrez ID		7270	25861
HPRD ID		02866	09718
Ensembl ID		ENSG00000125482	ENSG00000095397
Uniprot IDs		A0A087WY09 Q15361	B9EGE6 Q9P202
PDB IDs			1UEZ 1UF1 1UFX 6KZ1 7EP7
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Transcription Regulator Complex Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Regulation Of Cartilage Development Negative Regulation Of Muscle Cell Differentiation Protein-containing Complex Kidney Epithelium Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Orexigenic Neuropeptide QRFP Receptor Binding Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Chondrocyte Development DN4 Thymocyte Differentiation Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity NoRC Complex Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance DNA-templated Transcription Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Stereocilia Ankle Link USH2 Complex Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Activin Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of Chondrocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Ribosome Biogenesis L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose	Stereocilium Base Stereocilium Mitotic Spindle Organization Auditory Receptor Cell Stereocilium Organization
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