C6 and MGEA5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		C6	MGEA5
Gene Name		complement component 6	meningioma expressed antigen 5 (hyaluronidase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Vesicular Exosome	Nucleus Cytosol Membrane
	Molecular Function	Protein Binding	Histone Acetyltransferase Activity Hyalurononglucosaminidase Activity Beta-N-acetylglucosaminidase Activity
	Biological Process	In Utero Embryonic Development Positive Regulation Of Activation Of Membrane Attack Complex Complement Activation Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Angiogenesis	N-acetylglucosamine Metabolic Process Glycoprotein Catabolic Process Protein Deglycosylation Protein Targeting To Membrane Aging Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Adaptation Histone Acetylation Positive Regulation Of Cell Killing Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Proteolysis DATP Metabolic Process Positive Regulation Of Glucose Import Response To Steroid Hormone Positive Regulation Of DNA Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Glycosylation Positive Regulation Of Growth Hormone Secretion Necrotic Cell Death
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System
Drugs
Diseases
GWAS		Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		4 interactors: C5 F2 MGEA5 SART3	10 interactors: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32
Entrez ID		729	10724
HPRD ID		01956	04949
Ensembl ID		ENSG00000039537	ENSG00000198408
Uniprot IDs		P13671	E9PGF9 O60502
PDB IDs		3T5O 4A5W 4E0S	2YDQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cellular Protein Metabolic Process Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Ion Transport Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Transport Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone Deubiquitination Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Ion Homeostasis Protein Activation Cascade Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Cardiac Muscle Adaptation Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Positive Regulation Of Protein Secretion Positive Regulation Of Ion Transport Positive Regulation Of Metabolic Process Leukocyte Migration Positive Regulation Of Intracellular Transport Protein Deglycosylation Negative Regulation Of Protein Glycosylation Homeostatic Process Negative Regulation Of Dopamine Secretion Cellular Calcium Ion Homeostasis Regulation Of Protein Deubiquitination Calcium Ion Homeostasis Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Growth Hormone Secretion DATP Metabolic Process Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Secretion Positive Regulation Of Chemokine Secretion Regulation Of Growth Hormone Secretion Regulation Of Protein Glycosylation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Fibrinolysis Regulation Of Protein Processing Cellular Metal Ion Homeostasis	Regulation Of Protein Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Axon Guidance Regulation Of Cellular Protein Metabolic Process Axonogenesis Circadian Rhythm Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Protein Metabolic Process Regulation Of Complement Activation Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Binding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Regulation Of Humoral Immune Response Regulation Of Signal Transduction Rhythmic Process Cell Projection Morphogenesis Negative Regulation Of Protein Binding Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process Response To External Stimulus Cellular Response To Heat Neuron Development Intracellular Signal Transduction Regulation Of Signaling Regulation Of Acute Inflammatory Response Regulation Of Generation Of Precursor Metabolites And Energy Cell Morphogenesis Regulation Of Protein Phosphorylation Cell Differentiation Neuron Differentiation Cell Projection Organization Negative Regulation Of Binding Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Negative Regulation Of Complement Activation, Lectin Pathway Locomotion Establishment Of Cell Polarity Response To Heat
Tagcloud ?		appeared confluence confluent conversely culture d differentially exponential glioma half igf ir ka largest late later mannose phase phases phosphate post scatchard seeding showing stage stages statistically stopped values	alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably
Tagcloud (Difference) ?		appeared confluence confluent conversely culture d differentially exponential glioma half igf ir ka largest late later mannose phase phases phosphate post scatchard seeding showing stage stages statistically stopped values	alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably
Tagcloud (Intersection) ?