KEL and EDN1

Number of citations of the paper that reports this interaction (PMID 10438732)
14

Data Source:
HPRD (in vitro)

		KEL	EDN1
Gene Name		Kell blood group, metallo-endopeptidase	endothelin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cytoplasm Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding
	Biological Process	Proteolysis Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Prostaglandin Biosynthetic Process Patterning Of Blood Vessels In Utero Embryonic Development Histamine Secretion Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of PH Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Heart Development Respiratory Gaseous Exchange Body Fluid Secretion Positive Regulation Of Cell Proliferation Dorsal/ventral Pattern Formation Response To Ozone Multicellular Organismal Aging Positive Regulation Of Heart Rate Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Receptor Biosynthetic Process Neural Crest Cell Development Phosphatidylinositol 3-kinase Signaling Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Glucose Transport Cell Growth Regulation Of Vasoconstriction Sensory Perception Of Pain Calcium-mediated Signaling Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Negative Regulation Of CAMP Biosynthetic Process Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Response To Nicotine Cellular Response To Drug Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Protein Kinase C Deactivation Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAP Kinase Activity Positive Regulation Of JUN Kinase Activity Response To Leptin Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Cartilage Development Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Membrane Depolarization Regulation Of Sensory Perception Of Pain Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Calcium Ion Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Neutrophil Chemotaxis Response To Salt
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Circulating vasoactive peptide levels ( 23381795)
Protein-Protein Interactions		7 interactors: EDN1 EDN2 EDN3 EWSR1 TUBA1A UBC XK	10 interactors: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4
Entrez ID		3792	1906
HPRD ID		00194	07030
Ensembl ID		ENSG00000197993	ENSG00000078401
Uniprot IDs		P23276	P05305 Q6FH53
PDB IDs			1EDN 1EDP 1T7H 1V6R
Enriched GO Terms of Interacting Partners?		Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Positive Regulation Of Heart Rate Positive Regulation Of Heart Contraction Vasoconstriction Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Regulation Of Vasoconstriction Smooth Muscle Contraction Positive Regulation Of Leukocyte Chemotaxis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Positive Regulation Of Leukocyte Migration Tonic Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Cellular Metal Ion Homeostasis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of Behavior Metal Ion Homeostasis Regulation Of Chemotaxis Second-messenger-mediated Signaling Cellular Chemical Homeostasis Magnesium Ion Homeostasis Ion Homeostasis Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Regulation Of Blood Pressure Regulation Of Behavior Prostaglandin Biosynthetic Process Cellular Homeostasis Positive Regulation Of MAP Kinase Activity Response To Cytokine Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Prostaglandin Metabolic Process Muscle System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Oxidoreductase Activity Chemical Homeostasis Positive Regulation Of Cell Cycle	Blood Circulation Regulation Of Blood Pressure Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Endothelin Receptor Signaling Pathway Vasoconstriction Peptide Hormone Processing Hormone Metabolic Process Cellular Chemical Homeostasis Organ Development Regulation Of Hormone Levels Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Calcium Ion Homeostasis Cellular Homeostasis Calcium Ion Homeostasis Regulation Of Protein Metabolic Process Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Aging Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of CAMP Metabolic Process Enteric Nervous System Development Chemical Homeostasis Vascular Smooth Muscle Contraction Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Peptide Metabolic Process Metal Ion Homeostasis System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Ion Homeostasis Negative Regulation Of CAMP Biosynthetic Process Cyclic-nucleotide-mediated Signaling Negative Regulation Of CAMP Metabolic Process Multicellular Organismal Development Anatomical Structure Development Protein Processing Nervous System Development Negative Regulation Of Nucleotide Metabolic Process Homeostatic Process Cellular Amide Metabolic Process Tube Development Autonomic Nervous System Development Regulation Of Inflammatory Response Proteolysis
Tagcloud ?		abortions anomaly behave comes couples desert disequilibrium distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually	19q13 6p23 ankyloglossia bcl3 causation cleft disequilibrium exemplify indictment inheritance lip malformation mendelian merely monogenic multigenic nurture orofacial palatal palate parametric pedigrees penetrance recognised rests syndromic tentative teratogenic teratogens
Tagcloud (Difference) ?		abortions anomaly behave comes couples desert distortion epistatically fertility grc haplotypes histocompatibility hla homozygosity homozygotes immunogenetic inbreeding kummer linkage nomads reacts reproduction rt1 segregation specificities sterility tuaregs unusually	19q13 6p23 ankyloglossia bcl3 causation cleft exemplify indictment inheritance lip malformation mendelian merely monogenic multigenic nurture orofacial palatal palate parametric pedigrees penetrance recognised rests syndromic tentative teratogenic teratogens
Tagcloud (Intersection) ?		disequilibrium