KEL and AGPS

Data Source: HiPPIP (Novel)

		KEL	AGPS
Name		Kell metallo-endopeptidase (Kell blood group)	alkylglycerone phosphate synthase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Catalytic Activity Protein Binding Alkylglycerone-phosphate Synthase Activity Transferase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Proteolysis Intracellular Calcium Ion Homeostasis Regulation Of Cell Size Intracellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport	Lipid Metabolic Process Lipid Biosynthetic Process Ether Lipid Biosynthetic Process
Pathways		Peptide ligand-binding receptors	Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Phosphoramidon	None
Diseases		None	Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)
GWAS		Alcoholic chronic pancreatitis ( 28754779 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 )	Height ( 28552196 )
Novel Interactors		2 novel interactors: AGPS EMC1	12 novel interactors: BLVRA BOLL CHRND CS FKBP7 GORASP2 KCNH7 KEL LST1 NFIA PDE11A TSFM
Interacting Genes		12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK	2 interacting genes: GNPAT GORASP1
Entrez ID		3792	8540
HPRD ID		00194	04337
Ensembl ID		ENSG00000197993	ENSG00000018510
Uniprot IDs		A0A077QP03 P23276	B7Z3Q4 O00116
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Endothelin B Receptor Binding Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Hormone Activity Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Heart Contraction Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure Axon Extension Regulation Of Blood Pressure Positive Regulation Of Muscle Contraction Intracellular Magnesium Ion Homeostasis Neutrophil Chemotaxis Smooth Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Cell Chemotaxis Regulation Of Chemotaxis Regulation Of Vasoconstriction Neutrophil Migration Positive Regulation Of Prostaglandin Biosynthetic Process Calcium Ion Homeostasis Regulation Of Leukocyte Migration Leukocyte Migration Granulocyte Chemotaxis Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Extension Endothelin Receptor Signaling Pathway Regulation Of Prostaglandin Biosynthetic Process Magnesium Ion Homeostasis Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Fatty Acid Metabolic Process Regulation Of Cell Migration Regulation Of Heart Rate Regulation Of Cell Motility Regulation Of Locomotion Chemotaxis Developmental Cell Growth Response To Tumor Necrosis Factor Regulation Of Ketone Metabolic Process Myeloid Leukocyte Migration Locomotion	None