C4BPB and PROS1

Number of citations of the paper that reports this interaction (PubMedID 12492479)
0

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		C4BPB	PROS1
Description		complement component 4 binding protein beta	protein S
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Immune System Process Complement Activation, Classical Pathway Blood Coagulation Response To Symbiotic Bacterium Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization	Blood Coagulation Hemostasis Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Regulation of Complement cascade	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	Inherited thrombophilia
GWAS		C4b binding protein levels ( 20212171) Hip circumference ( 28552196)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		1 interacting genes: PROS1	11 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3 VWF
Entrez ID		725	5627
HPRD ID		00404	01473
Ensembl ID		ENSG00000123843	ENSG00000184500
Uniprot IDs		P20851	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs			1Z6C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Platelet Alpha Granule Lumen Regulation Of Hemostasis Fibrinolysis Coagulation Regulation Of Blood Coagulation Blood Coagulation Golgi Lumen Negative Regulation Of Hemostasis Endopeptidase Inhibitor Activity Hemostasis Negative Regulation Of Coagulation Blood Microparticle Regulation Of Wound Healing Regulation Of Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Body Fluid Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Golgi Lumen Endoplasmic Reticulum Lumen Extracellular Region Extracellular Space Response To Symbiotic Bacterium Response To Symbiont Negative Regulation Of Complement Activation, Classical Pathway Platelet Activation Platelet Alpha Granule Lumen Regulation Of Opsonization Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Complement Activation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Platelet Alpha Granule Serine-type Peptidase Activity Regulation Of Complement Activation Defense Response To Symbiont Defense Response To Other Organism Immune Effector Process Regulation Of Biological Quality Serine-type Endopeptidase Activity Plasma Membrane Biological Process Involved In Interaction With Host Defense Response Complement Activation, Classical Pathway COPII-coated ER To Golgi Transport Vesicle Acute-phase Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Copper Ion Binding Response To Stress Negative Regulation Of Coagulation Complement Activation Humoral Immune Response Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Acute Inflammatory Response Innate Immune Response Positive Regulation Of Cell Communication Cell Activation Positive Regulation Of Signaling Regulation Of Blood Coagulation
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