TRPS1 and RNF4

Number of citations of the paper that reports this interaction (PMID 12885770)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TRPS1	RNF4
Gene Name		trichorhinophalangeal syndrome I	ring finger protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm PML Body
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Ligase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Chondrocyte Differentiation Transcription From RNA Polymerase II Promoter NLS-bearing Protein Import Into Nucleus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Histone Deacetylation Regulation Of Chondrocyte Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Transcription, DNA-templated Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Eating disorders ( 22911880) HDL cholesterol ( 20686565) Major depressive disorder ( 22472876) Periodontal microbiota ( 22699663) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		3 interactors: RNF4 SUMO1 UBE2I	37 interactors: AR ATXN1 ESR1 GSC2 HIST2H3C HMGA1 HNF4A IKBKG MECP2 PATZ1 PGR PML SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TRAIP TRIM28 TRPS1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2T UBE2W UEVLD
Entrez ID		7227	6047
HPRD ID		05091	04167
Ensembl ID		ENSG00000104447	ENSG00000063978
Uniprot IDs		Q9UHF7	P78317
PDB IDs			2EA6 2XEU
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of SUMO Transferase Activity Post-translational Protein Modification Regulation Of Kinetochore Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Peptidyl-lysine Modification Proteasomal Protein Catabolic Process Regulation Of Centromere Complex Assembly PML Body Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Complex Assembly Protein Localization To Nuclear Pore Protein Localization To Nuclear Envelope Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Spindle Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Response To Interferon-gamma Positive Regulation Of Metabolic Process Response To Arsenic-containing Substance Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Peptidyl-amino Acid Modification Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Negative Regulation Of DNA Binding Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Proteasomal Protein Catabolic Process	Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Transcription Initiation From RNA Polymerase II Promoter Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Modification-dependent Protein Catabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Aromatic Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway ISG15-protein Conjugation
Tagcloud ?		biochemically bmp e14 e17 e18 eda edar embryos follicle follicles hair hedgehog histologically indirectly ko noggin phalangeal properly representative rescued rhino skin skins smad1 sonic sparse tricho wt	barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal
Tagcloud (Difference) ?		biochemically bmp e14 e17 e18 eda edar embryos follicle follicles hair hedgehog histologically indirectly ko noggin phalangeal properly representative rescued rhino skin skins smad1 sonic sparse tricho wt	barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal
Tagcloud (Intersection) ?