TRPS1

Gene Name		trichorhinophalangeal syndrome I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Chondrocyte Differentiation Transcription From RNA Polymerase II Promoter NLS-bearing Protein Import Into Nucleus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Histone Deacetylation Regulation Of Chondrocyte Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Eating disorders ( 22911880) HDL cholesterol ( 20686565) Major depressive disorder ( 22472876) Periodontal microbiota ( 22699663) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-protein Interactions		3 interactors: RNF4 SUMO1 UBE2I
Entrez ID		7227
HPRD ID		05091
Ensembl ID		ENSG00000104447
Uniprot IDs		Q9UHF7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of SUMO Transferase Activity Post-translational Protein Modification Regulation Of Kinetochore Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Peptidyl-lysine Modification Proteasomal Protein Catabolic Process Regulation Of Centromere Complex Assembly PML Body Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Complex Assembly Protein Localization To Nuclear Pore Protein Localization To Nuclear Envelope Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Spindle Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Response To Interferon-gamma Positive Regulation Of Metabolic Process Response To Arsenic-containing Substance Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Peptidyl-amino Acid Modification Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Negative Regulation Of DNA Binding Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		biochemically bmp e14 e17 e18 eda edar embryos follicle follicles hair hedgehog histologically indirectly ko noggin phalangeal properly representative rescued rhino skin skins smad1 sonic sparse tricho wt