TPO and DUSP6

		TPO	DUSP6
Description		thyroid peroxidase	dual specificity phosphatase 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	MAPK Cascade Signal Transduction Response To Xenobiotic Stimulus Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor
Pathways		Thyroxine biosynthesis	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs		Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 27182965 30367059) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183 24722205) Thyroid stimulating hormone levels ( 32769997)	Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: DUOX1 TXNDC11	12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212
Entrez ID		7173	1848
HPRD ID		06000	04124
Ensembl ID		ENSG00000115705	ENSG00000139318
Uniprot IDs		P07202 Q502Y3 Q6P534	Q16828 Q53GP9
PDB IDs			1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Protein Tyrosine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Reactive Oxygen Species Biosynthetic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process NADPH Oxidase Complex NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Catabolic Process Superoxide-generating NAD(P)H Oxidase Activity Hydrogen Peroxide Biosynthetic Process Cuticle Development Superoxide Anion Generation Peroxidase Activity Hydrogen Peroxide Metabolic Process NADP Binding Hormone Biosynthetic Process Superoxide Metabolic Process	Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Phosphorylation Protein Autophosphorylation ATP Binding ERBB2 Signaling Pathway Protein Serine Kinase Activity Interleukin-34-mediated Signaling Pathway Protein Serine/threonine Kinase Activity Nucleotide Binding Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neuroinflammatory Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Cellular Developmental Process MAP Kinase Activity GABA Receptor Binding Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Gland Development Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Face Development Peptidyl-threonine Phosphorylation Stress-activated MAPK Cascade Cell Development
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