TNNC2 and TBC1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNNC2	TBC1D1
Description		troponin C2, fast skeletal type	TBC1 domain family member 1
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex	Nucleus Cytoplasm Golgi Apparatus
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Metal Ion Binding	GTPase Activator Activity Protein Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction	Regulation Of Cilium Assembly
Pathways		Striated Muscle Contraction	Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs		Felodipine Calcium Octylphenoxy polyethoxyethanol
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23266558 23850713) Diastolic blood pressure ( 27618452 27841878) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: PIK3R3 TBC1D1 TNNI2 TNNI3	31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1
Entrez ID		7125	23216
HPRD ID		08929	18161
Ensembl ID		ENSG00000101470	ENSG00000065882
Uniprot IDs		C9J7T9 P02585	A0A8V8TNS9 B9A6J6 Q6PJJ8 Q86TI0 Q8NC59
PDB IDs		7KAA	3QYE
Enriched GO Terms of Interacting Partners?		Troponin T Binding Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiac Troponin Complex Troponin C Binding Muscle Contraction Muscle System Process 1-phosphatidylinositol-3-kinase Regulator Activity Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Myofibril Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Actin Binding Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Actin-myosin Filament Sliding Negative Regulation Of Anoikis Phosphatidylinositol-3-phosphate Biosynthetic Process Heart Contraction Cell Migration Involved In Sprouting Angiogenesis Regulation Of Anoikis Heart Process Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Blood Vessel Endothelial Cell Migration	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Spindle Microtubule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Protein Kinase C Inhibitor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cytoskeleton Regulation Of Synaptic Plasticity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Presynaptic Endocytosis Positive Regulation Of Sequestering Of Calcium Ion Substantia Nigra Development Calcium Channel Regulator Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cellular Response To Nitrogen Starvation Cell Cycle G2/M Phase Transition Spindle Pole Neural Nucleus Development Adenylate Cyclase Binding Regulation Of Muscle Contraction Negative Regulation Of Cation Transmembrane Transport Calcium Channel Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Phosphatidylethanolamine Binding Vesicle Regulation Of Voltage-gated Calcium Channel Activity
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