AIRIM and NUP54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AIRIM	NUP54
Description		AFG2 interacting ribosome maturation factor	nucleoporin 54
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Nuclear Pore Central Transport Channel
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis	NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Protein Localization To Nuclear Inner Membrane MRNA Transport
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS			Age at first birth ( 34211149) Hippocampal volume ( 29274321)
Interacting Genes		144 interacting genes: ABI2 ADD1 ANTKMT ATP23 AVPI1 BORCS6 C1orf94 C1QTNF2 CBY2 CCDC120 CCDC125 CCDC33 CCDC88B CCHCR1 CDCA4 CEP55 CINP CRX CSNK2A1 CT55 CTAG1A CTAG1B DISC1 ECM1 ECSIT FAM217B FAM86C1P FTO GET4 GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 HESX1 HOOK2 HOXC8 IHO1 IKZF1 IKZF3 INKA1 KATNAL1 KIAA0753 KIFC3 KLF15 KRT13 KRT16 KRT18 KRT19 KRT24 KRT31 KRT35 KRT40 KRT75 KRT76 KRT80 KRTAP13-3 LDOC1 LMO2 LZTS2 MBD3L1 MDM4 MEI4 MEOX1 MEOX2 MIPOL1 MKRN2 MTFR1L MTUS2 NDUFB7 NECAB2 NFKBID NME4 NUP54 NUTM2F OOEP PAX5 PAX6 PAX7 PBX4 PDE4DIP PHC2 PLK4 PNMA1 POMC POU6F2 PPP1R12C PRDM6 PRMT5 PSMB4 PUDP REL RINT1 RNF20 RNF41 RPH3AL RUSC1 SAPCD2 SDCBP SERTAD1 SERTAD2 SLAIN1 SMARCD1 SOCS6 SORBS3 SPAG5 SPMIP6 STMN3 STN1 STX11 TADA2A TASOR2 TCF12 TCF4 TEKT4 TEPSIN TFIP11 TLE5 TNNI2 TRAF1 TRIM27 TRIM42 TRIM54 TSGA10IP TTC12 TTC23 TTC23L UHMK1 USH1G USHBP1 VBP1 VGLL1 VPS52 YPEL3 ZBED1 ZBTB42 ZMAT1 ZMAT5 ZMYND12 ZNF17 ZNF20 ZNF398 ZNF420 ZNF688 ZSCAN9	46 interacting genes: AGR2 AIRIM AP1B1 AP2B1 APC BPIFA1 C14orf119 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OGT OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT
Entrez ID		54955	53371
HPRD ID		07918	06352
Ensembl ID		ENSG00000116922	ENSG00000138750
Uniprot IDs		B4DRQ5 B7Z9X8 Q9NX04	A0A8Q3SHX2 A0A8Q3WLP2 Q7Z3B4
PDB IDs		8RHN	4JNU 4JNV 4JO7 4JO9 5IJN 5IJO 7N8R 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Organization Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Structural Molecule Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Centrosome Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Transcription Coactivator Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Microtubule Somite Specification	Cytoskeleton Cytoskeleton-dependent Cytokinesis Centrosome Organelle Assembly Cell Division Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Establishment Of Protein Localization Membrane Fission Microtubule-based Process Intracellular Protein Transport Nuclear Import Signal Receptor Activity Organelle Organization Protein Transport Mitotic Cytokinesis Cytosol Spindle Cellular Localization Chromosome Localization Spindle Pole Regulation Of Microtubule-based Process Nuclear Pore Protein Binding Nuclear Pore Central Transport Channel Membraneless Organelle Assembly Keratin Filament Mitotic Spindle Organization Positive Regulation Of Protein Localization To Centrosome Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Hsp90 Protein Binding Metaphase/anaphase Transition Of Cell Cycle HAUS Complex Regulation Of Sister Chromatid Segregation Vesicle Tethering Involved In Exocytosis Intracellular Protein Localization Mitotic Metaphase Chromosome Alignment Organelle Localization NLS-dependent Protein Nuclear Import Complex Centrosome Cycle Regulation Of Mitotic Nuclear Division Protein Import Into Nucleus Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Organelle Import Into Nucleus Clathrin Adaptor Complex Regulation Of Protein Localization To Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation
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