ESRRA and TNNI2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ESRRA	TNNI2
Name		estrogen related receptor alpha	troponin I2, fast skeletal type
Structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge	Nucleus Cytosol Troponin Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Troponin T Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Skeletal Muscle Contraction Positive Regulation Of DNA-templated Transcription Cardiac Muscle Contraction
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	Striated Muscle Contraction
Drugs		Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone	None
Diseases		None	Distal arthrogryposis (DA)
GWAS		Crohn's disease ( 21102463 28067908 ) Vitiligo ( 27723757 )	Celiac disease ( 23936387 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Inflammatory bowel disease ( 23128233 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Interacting Genes		37 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FAM9A FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA2 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARG PPARGC1A PRKCD PROX1 PSMC5 REL RNF4 RXRA SIRT1 SMARCD3 SP1 TNNI2	21 interacting genes: ACTB AIRIM CALM1 CTNNA3 DCAF11 DRC8 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		2101	7136
HPRD ID		07210	01843
Ensembl ID		ENSG00000173153	ENSG00000130598
Uniprot IDs		P11474 Q569H8	P48788
PDB IDs		1XB7 2PJL 3D24 3K6P 7E2E	2MKP 7KAA
GO Terms Enriched among Interactors		Nuclear Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Adipose Tissue Development Negative Regulation Of Metabolic Process Regulation Of Lipid Metabolic Process Transcription Coregulator Binding Nuclear Retinoic Acid Receptor Binding DNA Binding Domain Binding Regulation Of Adipose Tissue Development Retinoic Acid Receptor Signaling Pathway Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity LBD Domain Binding Circadian Regulation Of Gene Expression	Troponin Complex Regulation Of Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Regulation Of System Process Nuclear Receptor Activity Striated Muscle Contraction Muscle Contraction Troponin I Binding Troponin T Binding Muscle System Process Transition Between Fast And Slow Fiber System Process Estrogen Response Element Binding Regulation Of Skeletal Muscle Adaptation Titin Binding Contractile Muscle Fiber Tropomyosin Binding Calcium-dependent Protein Binding Motile Cilium Intracellular Receptor Signaling Pathway Calyx Of Held Regulation Of Striated Muscle Contraction Nuclear Steroid Receptor Activity Axonemal A Tubule Inner Sheath Calcium Channel Complex Regulation Of Cardiac Muscle Cell Action Potential Steroid Binding Respiratory System Process Cilium Axonemal Microtubule Calcium Ion Binding Eye Photoreceptor Cell Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Photoreceptor Cell Development Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Regulation Of Muscle Filament Sliding Speed Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Substantia Nigra Development Actin Filament-based Process Cytosol Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Heart Contraction