ESRRA and NCOA1

Number of citations of the paper that reports this interaction (PMID 11165056)
8

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		ESRRA	NCOA1
Gene Name		estrogen-related receptor alpha	nuclear receptor coactivator 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Microtubule Cytoskeleton Intercellular Bridge	Nuclear Chromatin Nucleoplasm Cytoplasm Neuron Projection
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Protein Complex Binding Progesterone Receptor Binding Nuclear Hormone Receptor Binding Retinoid X Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Gene Expression Intracellular Receptor Signaling Pathway Regulation Of Cell Proliferation Steroid Hormone Mediated Signaling Pathway Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cartilage Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Transcription, DNA-templated Lactation Male Gonad Development Cerebellum Development Hippocampus Development Hypothalamus Development Cerebral Cortex Development Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Response To Estradiol Response To Retinoic Acid Response To Progesterone Cellular Response To Hormone Stimulus Ovulation Cycle Positive Regulation Of Apoptotic Process Histone H4 Acetylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Male Mating Behavior Labyrinthine Layer Morphogenesis Regulation Of Cellular Response To Drug
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	PPARA activates gene expression Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Generic Transcription Pathway Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Transcriptional regulation of white adipocyte differentiation Biological oxidations Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) REV-ERBA represses gene expression Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Mitochondrial biogenesis Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)
Protein-Protein Interactions		34 interactors: ADH5 ATXN1 DPF1 DPF2 DPF3 DUT EIF3I ESR1 ESRRG EXOSC6 FUS GTF2B HDAC8 KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARGC1A PRKCD PROX1 SIRT1 SMARCD3 SP1 SRC TNNI2	72 interactors: AHR AR ARNT BCL3 CARM1 CCND1 CIITA COPS5 CREBBP CXADR DDX17 DDX5 EP300 ESR1 ESR2 ESRRA ESRRG FOS FOXA2 GTF2B HIF1A HNF4A HNF4G JUN KANK2 KAT2B MAPK1 NCOA6 NCOR1 NFKB1 NKX2-1 NR1H4 NR1I2 NR1I3 NR2F1 NR2F6 NR3C1 NR4A1 NR5A1 NR5A2 NR6A1 PAGR1 PGR PPARA PPARD PPARG PPARGC1A PRMT1 PRMT2 PSMB9 RARA RARB RARG RORA RORB RXRA RXRB SMARCE1 SRF STAT3 STAT6 SUMO1 TBP TEAD1 TEAD2 THRA THRB TP53 TRIP4 VDR YWHAH YWHAQ
Entrez ID		2101	8648
HPRD ID		07210	04070
Ensembl ID		ENSG00000173153	ENSG00000084676
Uniprot IDs		P11474 Q569H8	Q15788
PDB IDs		1XB7 2PJL 3D24 3K6P	1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE 1ZAF 2A3I 2C52 2FVJ 2GTK 2HBH 2HC4 2HCD 2HFP 2NPA 2NV7 2P54 2PRG 3BEJ 3BQD 3CTB 3CWD 3DCT 3DCU 3DR1 3ET1 3ET3 3FEI 3FEJ 3FUR 3FXV 3G8I 3G9E 3H0A 3HC5 3HC6 3HVL 3IPQ 3IPS 3IPU 3KMR 3LMP 3OKH 3OKI 3OLF 3OLL 3OLS 3OMK 3OMM 3OMO 3OMP 3OMQ 3OOF 3OOK 3P88 3P89 3QT0 3RUT 3RUU 3RVF 3S9S 3T03 3UU7 3UUA 3UUD 3V9Y 3VN2 4DK7 4DK8 4DM6 4DM8 4DQM 4F9M 4FGY 4G1D 4G1Y 4G1Z 4G20 4G21 4G2H 4HEE 4J5X
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Receptor Signaling Pathway Biosynthetic Process Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Chromatin Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Androgen Receptor Signaling Pathway Reproductive Structure Development Negative Regulation Of Cellular Metabolic Process Reproductive System Development Chromatin Organization Response To Hormone	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Steroid Hormone Mediated Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Hormone-mediated Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Gene Expression Response To Steroid Hormone Cellular Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Cellular Response To Organic Cyclic Compound Response To Organic Cyclic Compound Response To Lipid Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cell Communication Negative Regulation Of Biosynthetic Process Signaling
Tagcloud ?		biogenesis constituent coregulated ctf1 dap3 elk1 elk4 exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated	bioenergy causally clearer clinicopathologies colonize coregulator coregulators decidual decidualization decidualize dovetailing endometriotic evade glycolytic launch minireview ncoa2 ncoa3 p160 pacemaker pathobiology pleiotropy proposal quiescence subfecundity tantalizing triad underexplored underpinning
Tagcloud (Difference) ?		biogenesis constituent coregulated ctf1 dap3 elk1 elk4 exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated	bioenergy causally clearer clinicopathologies colonize coregulator coregulators decidual decidualization decidualize dovetailing endometriotic evade glycolytic launch minireview ncoa2 ncoa3 p160 pacemaker pathobiology pleiotropy proposal quiescence subfecundity tantalizing triad underexplored underpinning
Tagcloud (Intersection) ?