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C1QB and PTX3
Number of citations of the paper that reports this interaction (PubMedID
12645945
)
0
Data Source:
HPRD
(in vitro)
C1QB
PTX3
Description
complement C1q B chain
pentraxin 3
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Cell Surface
Extracellular Matrix
Synapse
Complement Component C1q Complex
Blood Microparticle
Postsynapse
Symbiont Cell Surface
Extracellular Region
Extracellular Space
Extracellular Matrix
Specific Granule Lumen
Tertiary Granule Lumen
Molecular Function
Phosphatidylserine Binding
IgM Binding
Protein Binding
IgG Binding
Complement Component C1q Complex Binding
(1->3)-beta-D-glucan Binding
Protein Binding
Identical Protein Binding
Virion Binding
Biological Process
Immune System Process
Complement Activation
Complement Activation, Classical Pathway
Innate Immune Response
Synapse Pruning
Ovarian Cumulus Expansion
Response To Yeast
Immune System Process
Inflammatory Response
Immune Response
Opsonization
Extracellular Matrix Organization
Host-mediated Suppression Of Viral Proces
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Host-mediated Suppression Of Symbiont Invasion
Positive Regulation Of Phagocytosis
Response To Other Organism
Negative Regulation Of Glycoprotein Metabolic Process
Pathways
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Neutrophil degranulation
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Body mass index (
26426971
)
Interacting Genes
11 interacting genes:
C1QA
C1QC
C1R
DEFA1
EDA2R
HRG
IL32
MYOC
PTX3
RELA
UBQLN2
16 interacting genes:
C1QA
C1QB
C1QC
CFH
FGF1
FGF16
FGF17
FGF18
FGF2
FGF20
FGF22
FGF5
FGF7
FGF8
MTNR1A
SNCA
Entrez ID
713
5806
HPRD ID
00394
03928
Ensembl ID
ENSG00000173369
ENSG00000163661
Uniprot IDs
A0A024RAB9
D6R934
P02746
P26022
PDB IDs
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
9C9L
9C9U
7ZL1
8PVQ
8S50
Enriched GO Terms of Interacting Partners
?
Complement Component C1 Complex
Immune Response
Defense Response To Other Organism
Defense Response To Symbiont
Defense Response
Symbiont Cell Surface
Humoral Immune Response
Complement Component C1q Complex
Response To Other Organism
Innate Immune Response
Complement Activation, Classical Pathway
Extrinsic Component Of Presynaptic Membrane
Immune System Process
IgM Binding
Response To External Biotic Stimulus
Complement Activation
Extracellular Region
Response To Fungus
Response To Stress
Extrinsic Component Of Postsynaptic Membrane
Synapse Pruning
IgG Binding
Positive Regulation Of Immune Response
Opsonization
Blood Microparticle
Killing Of Cells Of Another Organism
Immune Effector Process
Activation Of Immune Response
Extracellular Matrix
Extracellular Space
Positive Regulation Of Focal Adhesion Assembly
Killing By Host Of Symbiont Cells
Regulation Of Immune Response
Cell Killing
Positive Regulation Of Immune System Process
Biological Process Involved In Interaction With Symbiont
Cell Surface
Defense Response To Fungus
Phosphatidylserine Binding
Skeletal Muscle Hypertrophy
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Cell-matrix Adhesion
Regulation Of Focal Adhesion Assembly
Collagen Trimer
Negative Regulation Of Viral Process
Regulation Of Cell-substrate Junction Organization
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
(1->3)-beta-D-glucan Binding
NF-kappaB P50/p65 Complex
Positive Regulation Of Type III Interferon Production
Fibroblast Growth Factor Receptor Signaling Pathway
Neurogenesis
Growth Factor Activity
Fibroblast Growth Factor Receptor Binding
Extracellular Region
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of MAPK Cascade
Type 2 Fibroblast Growth Factor Receptor Binding
Extracellular Space
Cell-cell Signaling
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Signaling
Enzyme-linked Receptor Protein Signaling Pathway
Cell Communication
Regulation Of MAPK Cascade
Regulation Of Locomotion
Complement Component C1q Complex
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Cell Population Proliferation
Symbiont Cell Surface
Regulation Of Cell Migration
Regulation Of Cell Motility
IgM Binding
Complement Component C1 Complex
Positive Regulation Of Intracellular Signal Transduction
Type 1 Fibroblast Growth Factor Receptor Binding
Positive Regulation Of Cell Division
Lung Development
Postsynapse
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Synapse Pruning
Complement Activation
Regulation Of Sprouting Angiogenesis
IgG Binding
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Chemotaxis
Regulation Of Cell Population Proliferation
Regulation Of MAP Kinase Activity
Regulation Of Cell Division
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Animal Organ Morphogenesis
Organ Induction
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Animal Organ Formation
Corticotropin Hormone Secreting Cell Differentiation
Developmental Induction
Chemoattractant Activity
Positive Regulation Of Endothelial Cell Migration
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Tagcloud (Intersection)
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