C1QB and HRG

Number of citations of the paper that reports this interaction (PubMedID 9184145)
0

Data Source:
HPRD (in vivo)

		C1QB	HRG
Description		complement C1q B chain	histidine rich glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Symbiont Cell Surface	Extracellular Region Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding
	Biological Process	Immune System Process Complement Activation Complement Activation, Classical Pathway Innate Immune Response Synapse Pruning	Angiogenesis Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Hemostasis Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Cytolysis By Host Of Symbiont Cells Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Platelet degranulation Dissolution of Fibrin Clot
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Inherited thrombophilia
GWAS			Activated partial thromboplastin time ( 20303064 22703881) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neurological blood protein biomarker levels ( 31320639) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2	15 interacting genes: C1QA C1QB CHRD CYSRT1 FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 RGS20 SPRY1 THBS1 TNFRSF1A
Entrez ID		713	3273
HPRD ID		00394	00812
Ensembl ID		ENSG00000173369	ENSG00000113905
Uniprot IDs		A0A024RAB9 D6R934 P02746	P04196
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
Enriched GO Terms of Interacting Partners?		Complement Component C1 Complex Immune Response Defense Response To Other Organism Defense Response To Symbiont Defense Response Symbiont Cell Surface Humoral Immune Response Complement Component C1q Complex Response To Other Organism Innate Immune Response Complement Activation, Classical Pathway Extrinsic Component Of Presynaptic Membrane Immune System Process IgM Binding Response To External Biotic Stimulus Complement Activation Extracellular Region Response To Fungus Response To Stress Extrinsic Component Of Postsynaptic Membrane Synapse Pruning IgG Binding Positive Regulation Of Immune Response Opsonization Blood Microparticle Killing Of Cells Of Another Organism Immune Effector Process Activation Of Immune Response Extracellular Matrix Extracellular Space Positive Regulation Of Focal Adhesion Assembly Killing By Host Of Symbiont Cells Regulation Of Immune Response Cell Killing Positive Regulation Of Immune System Process Biological Process Involved In Interaction With Symbiont Cell Surface Defense Response To Fungus Phosphatidylserine Binding Skeletal Muscle Hypertrophy Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Collagen Trimer Negative Regulation Of Viral Process Regulation Of Cell-substrate Junction Organization Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding NF-kappaB P50/p65 Complex Positive Regulation Of Type III Interferon Production	Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex IgG Binding Platelet Alpha Granule Lumen Protein Activation Cascade Extracellular Matrix Complement Component C1q Complex Blood Microparticle Biological Process Involved In Interaction With Symbiont Defense Response IgM Binding Complement Component C1 Complex Cell Surface Phosphatidylserine Binding Acute Inflammatory Response Synapse Pruning Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Negative Regulation Of Fibrinolysis Proteoglycan Binding Inflammatory Response Regulation Of Fibrinolysis Protease Binding Symbiont Cell Surface Platelet Alpha Granule Fibrinolysis Extracellular Matrix Structural Constituent Protein Maturation Extracellular Region Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus External Side Of Plasma Membrane Negative Regulation Of Protein Maturation Response To Other Organism Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Phagocytosis, Engulfment Positive Regulation Of Coagulation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Stress Complement Activation, Classical Pathway Regulation Of Cell Adhesion Regulation Of Response To Wounding Response To External Biotic Stimulus Acute-phase Response Membrane Invagination High-affinity IgG Receptor Activity Regulation Of Cell Communication
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