C1QB and C1R

Number of citations of the paper that reports this interaction (PubMedID 1370572)
0

Data Source:
HPRD (in vivo)

		C1QB	C1R
Description		complement C1q B chain	complement C1r
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Symbiont Cell Surface	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Molecular Sequestering Activity
	Biological Process	Immune System Process Complement Activation Complement Activation, Classical Pathway Innate Immune Response Synapse Pruning	Activation Of Membrane Attack Complex Immune System Process Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Interacting Genes		11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2	7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		713	715
HPRD ID		00394	01954
Ensembl ID		ENSG00000173369	ENSG00000159403
Uniprot IDs		A0A024RAB9 D6R934 P02746	A0A3B3ISR2 B4DPQ0 P00736
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39 9EKD 9EKE
Enriched GO Terms of Interacting Partners?		Complement Component C1 Complex Immune Response Defense Response To Other Organism Defense Response To Symbiont Defense Response Symbiont Cell Surface Humoral Immune Response Complement Component C1q Complex Response To Other Organism Innate Immune Response Complement Activation, Classical Pathway Extrinsic Component Of Presynaptic Membrane Immune System Process IgM Binding Response To External Biotic Stimulus Complement Activation Extracellular Region Response To Fungus Response To Stress Extrinsic Component Of Postsynaptic Membrane Synapse Pruning IgG Binding Positive Regulation Of Immune Response Opsonization Blood Microparticle Killing Of Cells Of Another Organism Immune Effector Process Activation Of Immune Response Extracellular Matrix Extracellular Space Positive Regulation Of Focal Adhesion Assembly Killing By Host Of Symbiont Cells Regulation Of Immune Response Cell Killing Positive Regulation Of Immune System Process Biological Process Involved In Interaction With Symbiont Cell Surface Defense Response To Fungus Phosphatidylserine Binding Skeletal Muscle Hypertrophy Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Collagen Trimer Negative Regulation Of Viral Process Regulation Of Cell-substrate Junction Organization Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding NF-kappaB P50/p65 Complex Positive Regulation Of Type III Interferon Production	Complement Component C1 Complex Symbiont Cell Surface Complement Component C1q Complex Complement Activation, Classical Pathway Regulation Of Immune Response IgM Binding Complement Activation Positive Regulation Of Immune Response Synapse Pruning Regulation Of Immune System Process IgG Binding Blood Microparticle Activation Of Immune Response Tricarboxylic Acid Metabolic Process Positive Regulation Of Immune System Process Humoral Immune Response Gluconeogenesis Phosphatidylserine Binding Protein Maturation Hexose Biosynthetic Process Pyruvate Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Protein Serine Kinase Activity (using GTP As Donor) Collagen Trimer Immune Effector Process Negative Regulation Of Complement Activation, Lectin Pathway Extracellular Matrix Response To Stress Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process Response To Other Organism Protein Localization To Chromosome Carbohydrate Biosynthetic Process Vertebrate Eye-specific Patterning
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