CD46 and ANKRD46

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD46	ANKRD46
Description		CD46 molecule	ankyrin repeat domain 46
Image			No pdb structure
GO Annotations	Cellular Component	Inner Acrosomal Membrane Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Cytoplasmic Vesicle Extracellular Exosome	Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production
Pathways		Regulation of Complement cascade
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Early age-related macular degeneration ( 32843070) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Keratoconus ( 33649486) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Refractive error ( 32231278) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656 25056061) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)	Atrioventricular conduction ( 21041692) Body mass index ( 26426971) Percentage gas trapping ( 26030696)
Interacting Genes		14 interacting genes: AGR3 ANKRD46 C3 DLG4 GPR37L1 ITGB1 LLGL1 MGAT5B MSN POU4F2 SRC TSPAN4 VTI1B YES1	63 interacting genes: AMIGO1 APH1A AQP6 ARL13B BIK BSCL2 C16orf54 CD22 CD46 CLDN20 CLDN7 CLEC4D CRB3 CREB3L1 CXADR CYB561 EBP EFNB1 EFNB2 ELOVL4 FAM174A FAM209A FFAR2 GOLM1 GPR152 GPR42 GPX8 HSD17B11 HSD17B13 IFNLR1 KASH5 KIR2DL3 LAMTOR5 LDLRAD1 LRRC25 MFF MMGT1 MUC1 NCAPH2 NSG2 PLPP4 PVR RELL2 RETREG3 SCN3B SECTM1 SHISA3 SLC10A6 SLC16A2 SLC18A1 SLC39A9 ST6GALNAC6 STX1A STX2 STX4 SUSD3 THAP4 TIMMDC1 TMEM248 TMEM31 TMEM45B TMEM79 TMPRSS2
Entrez ID		4179	157567
HPRD ID		00406	14103
Ensembl ID		ENSG00000117335	ENSG00000186106
Uniprot IDs		A0A8Q3WLA6 P15529	B3KT99 Q86W74
PDB IDs		1CKL 2O39 3INB 3L89 3O8E 5FO8 8QK3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Transport Leukocyte Migration Regulation Of D-glucose Transmembrane Transport Protein Kinase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Negative Regulation Of Neuron Differentiation Focal Adhesion Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Cell Projection Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Regulation Of Endocytosis Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Regulation Of Anoikis Integrin Binding Perinuclear Region Of Cytoplasm Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signaling Receptor Binding Establishment Or Maintenance Of Cell Polarity Cellular Response To Fluid Shear Stress Antigen Binding Plasma Membrane Fc-gamma Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Cellular Response To Peptide Hormone Stimulus Vesicle Cell Projection Positive Regulation Of Protein Localization Regulation Of Cellular Component Organization Developmental Maturation Positive Regulation Of Transport C5L2 Anaphylatoxin Chemotactic Receptor Binding Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Developmental Process P2Y1 Nucleotide Receptor Binding Adherens Junction	Membrane Protein Binding Plasma Membrane Steroid Dehydrogenase Activity
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