CD46

Gene Name		CD46 molecule, complement regulatory protein
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Gene Ontology Annotations	Cellular Component	Inner Acrosomal Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Complement Binding Endopeptidase Activity Enzyme Inhibitor Activity Receptor Activity Protein Binding Cadherin Binding
	Biological Process	Adaptive Immune Response T Cell Mediated Immunity Proteolysis Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Regulation Of Complement Activation Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Negative Regulation Of Catalytic Activity Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Positive Regulation Of Transforming Growth Factor Beta Production
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Heart rate ( 23583979) Obesity-related traits ( 23251661)
Protein-protein Interactions		8 interactors: C3 DLG4 ITGB1 LLGL1 MSN SRC TSPAN4 YES1
Entrez ID		4179
HPRD ID		00406
Ensembl ID		ENSG00000117335
Uniprot IDs		P15529
PDB IDs		1CKL 1HR4 2O39 3INB 3L89 3O8E
Enriched GO Terms of Interacting Partners?		Regulation Of Endocytosis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Maintenance Of Apical/basal Cell Polarity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Vesicle-mediated Transport Axon Guidance Cell Development Neuron Development Maintenance Of Cell Polarity Cell Morphogenesis Negative Regulation Of Anoikis Neuron Differentiation Cell Projection Organization Regulation Of Anoikis Locomotion Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Immune System Process Actin Cytoskeleton Organization Chemotaxis Cortical Actin Cytoskeleton Organization Actin Filament-based Process Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Permeability Generation Of Neurons Golgi To Plasma Membrane Transport Peptidyl-tyrosine Autophosphorylation Neurogenesis Cell Migration Regulation Of Immune Response Cell Motility Cellular Component Assembly Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Adhesion Protein Complex Assembly Dendrite Morphogenesis Immune System Process T Cell Costimulation Blood Coagulation Cytoskeleton Organization
Tagcloud ?		abc accelerating acinar apical cd55 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces