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CD46
Description
CD46 molecule
Image
GO Annotations
Cellular Component
Inner Acrosomal Membrane
Extracellular Space
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Cytoplasmic Vesicle
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Protein Binding
Signaling Receptor Activity
Cadherin Binding
Biological Process
Adaptive Immune Response
Immune System Process
T Cell Mediated Immunity
Complement Activation, Classical Pathway
Single Fertilization
Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Interleukin-10 Production
Sequestering Of Extracellular Ligand From Receptor
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Memory T Cell Differentiation
Innate Immune Response
Positive Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of Complement Activation, Classical Pathway
Symbiont Entry Into Host Cell
Regulation Of Immune Response
Positive Regulation Of Transforming Growth Factor Beta Production
Pathways
Regulation of Complement cascade
Drugs
Diseases
GWAS
Age-related macular degeneration (
23326517
)
Biomedical quantitative traits (
19396169
)
Chronic central serous retinopathy (
30073298
)
Drug experimentation measurement (
30718321
)
Early age-related macular degeneration (
32843070
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Febrile seizures (
25344690
)
Febrile seizures (MMR vaccine-related) (
25344690
)
Heart rate (
23583979
)
Immune response to measles vaccine (measles-specific neutralising antibody titre) (
28289848
)
Keratoconus (
33649486
)
Obesity-related traits (
23251661
)
Pulse pressure (
27841878
)
Refractive error (
32231278
)
Resting heart rate (
29769521
27798624
)
Schizophrenia (
29483656
25056061
)
Systolic blood pressure (
27841878
30578418
)
White blood cell count (
32888494
)
Novel Interacting Genes
2 novel interacting genes:
NEK2
PRKACA
Interacting Genes
14 interacting genes:
AGR3
ANKRD46
C3
DLG4
GPR37L1
ITGB1
LLGL1
MGAT5B
MSN
POU4F2
SRC
TSPAN4
VTI1B
YES1
Entrez ID
4179
HPRD ID
00406
Ensembl ID
ENSG00000117335
Uniprot IDs
A0A8Q3WLA6
P15529
PDB IDs
1CKL
2O39
3INB
3L89
3O8E
5FO8
8QK3
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Cellular Component Organization
Regulation Of Transport
Leukocyte Migration
Regulation Of D-glucose Transmembrane Transport
Protein Kinase Binding
Establishment Or Maintenance Of Apical/basal Cell Polarity
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Neuromuscular Junction
Negative Regulation Of Neuron Differentiation
Focal Adhesion
Positive Regulation Of Podosome Assembly
Regulation Of Podosome Assembly
Regulation Of Anatomical Structure Morphogenesis
Neuron Projection Morphogenesis
Regulation Of Cellular Localization
Regulation Of Vesicle-mediated Transport
Cell Projection Morphogenesis
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Anoikis
Regulation Of Endocytosis
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Contractile Actin Filament Bundle Assembly
Stress Fiber Assembly
Fc Receptor Mediated Stimulatory Signaling Pathway
Response To Platelet-derived Growth Factor
Regulation Of Anoikis
Integrin Binding
Perinuclear Region Of Cytoplasm
Ionotropic Glutamate Receptor Binding
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Signaling Receptor Binding
Establishment Or Maintenance Of Cell Polarity
Cellular Response To Fluid Shear Stress
Antigen Binding
Plasma Membrane
Fc-gamma Receptor Signaling Pathway
Negative Regulation Of Smoothened Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Vesicle
Cell Projection
Positive Regulation Of Protein Localization
Regulation Of Cellular Component Organization
Developmental Maturation
Positive Regulation Of Transport
C5L2 Anaphylatoxin Chemotactic Receptor Binding
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Developmental Process
P2Y1 Nucleotide Receptor Binding
Adherens Junction
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