LY96

Description		lymphocyte antigen 96
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Endosome Membrane Receptor Complex Lipopolysaccharide Receptor Complex
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity Protein Binding Coreceptor Activity Toll-like Receptor 4 Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Response To Lipopolysaccharide
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions
Drugs		Morphine (R)-3-hydroxytetradecanoic acid Lauric acid Myristic acid
Diseases
GWAS		Carotid plaque burden (smoking interaction) ( 24954085) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Liver enzyme levels (alkaline phosphatase) ( 33972514) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043)
Novel Interacting Genes		1 novel interacting genes: ELOC
Interacting Genes		8 interacting genes: CALM1 CDKN2C LCN2 MESD MLH1 SMARCB1 TLR2 TLR4
Entrez ID		23643
HPRD ID		05579
Ensembl ID		ENSG00000154589
Uniprot IDs		Q9Y6Y9
PDB IDs		2E56 2E59 2Z65 3FXI 3ULA 4G8A 8WO1 8WTA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Type II Interferon Lipopolysaccharide Immune Receptor Activity Positive Regulation Of Gene Expression Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Lipoteichoic Acid Response To Type II Interferon Detection Of Molecule Of Bacterial Origin Detection Of Chemical Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Detection Of Biotic Stimulus Response To Peptide Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-12 Production Detection Of Stimulus Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Amyloid-beta Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Defense Response To Bacterium Response To Amyloid-beta B Cell Activation Involved In Immune Response Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Glial Cell Development Regulation Of Interleukin-12 Production Triacyl Lipopeptide Binding Positive Regulation Of Interleukin-8 Production Regulation Of Interferon-beta Production Nitric Oxide Production Involved In Inflammatory Response Response To Molecule Of Bacterial Origin Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication
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