LY96 and CDKN2C

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LY96	CDKN2C
Gene Name		lymphocyte antigen 96	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Endosome Membrane Lipopolysaccharide Receptor Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Lipopolysaccharide Receptor Activity Protein Binding Coreceptor Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Oligodendrocyte Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System	Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Ventricular conduction ( 21076409)
Protein-Protein Interactions		4 interactors: CALM1 CDKN2C TLR2 TLR4	27 interactors: AHCYL1 APLP1 ATM ATR CCDC90B CDK4 CDK6 CDKN2A COPS6 DRAP1 GDF9 GOPC LRIF1 LY96 MAPK10 MAPK8 NAGK NHP2L1 NIF3L1 PPP2CA RBM48 REL TCF12 TCF4 TLE1 TP53 UNC119
Entrez ID		23643	1031
HPRD ID		05579	04534
Ensembl ID		ENSG00000154589	ENSG00000123080
Uniprot IDs		E5RJJ7 Q9Y6Y9	P42773 Q6ICV4
PDB IDs		1T2Z 2E56 2E59 2Z65 3FXI 3ULA 4G8A	1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-17 Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Nitric Oxide Metabolic Process Detection Of Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-10 Production Reactive Nitrogen Species Metabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Response To Fungus Regulation Of Interferon-beta Production Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Nitric Oxide Biosynthetic Process Detection Of Chemical Stimulus Positive Regulation Of Chemokine Production Negative Regulation Of Phosphorylation Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-12 Production Regulation Of Intracellular Transport Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Detection Of Stimulus Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Type I Interferon Production Oligodendrocyte Differentiation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Replicative Senescence Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Cycle Arrest Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Cell Aging Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process RNA Metabolic Process Cell Cycle Negative Regulation Of Growth Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Signal Transduction Mitotic Cell Cycle JUN Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Positive Regulation Of Cell Aging Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Signaling Negative Regulation Of Cell Growth Response To Gamma Radiation Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Response To Light Stimulus Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Apoptotic Process Cell Communication Positive Regulation Of Programmed Cell Death Cellular Metabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Cell Death
Tagcloud ?		8v2 bad bead chips corrected ctla4 error false fdr genespring humanref hybridized il8 illumina inflation ingenuity institutes ipa mrs paxgene prove rankin recovery sdpr stroke tlr2 tlr4 tubes validation	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		8v2 bad bead chips corrected ctla4 error false fdr genespring humanref hybridized il8 illumina inflation ingenuity institutes ipa mrs paxgene prove rankin recovery sdpr stroke tlr2 tlr4 tubes validation	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?