LY96 and LCN2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LY96	LCN2
Name		lymphocyte antigen 96	lipocalin 2
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Endosome Membrane Receptor Complex Lipopolysaccharide Receptor Complex	Extracellular Region Extracellular Space Cytoplasmic Vesicle Specific Granule Lumen Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity Protein Binding Coreceptor Activity Toll-like Receptor 4 Binding	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Iron Ion Sequestering Activity Enterobactin Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Response To Lipopolysaccharide	Immune System Process Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Acute-phase Response Response To Oxidative Stress Short-term Memory Long-term Memory Response To Xenobiotic Stimulus Response To Virus Response To Bacterium Response To Herbicide Response To Toxic Substance Response To Blue Light Response To Fructose Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Response To Nutrient Levels Cellular Response To Nutrient Levels Response To Lipopolysaccharide Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To X-ray Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Kainic Acid Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs		Morphine (R)-3-hydroxytetradecanoic acid Lauric acid Myristic acid	Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
GWAS		Carotid plaque burden (smoking interaction) ( 24954085 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: CALM1 CDKN2C LCN2 MESD MLH1 SMARCB1 TLR2 TLR4	62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF CAMLG CCNC CDSN CHIC2 CIMIP1 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1
Entrez ID		23643	3934
HPRD ID		05579	02551
Ensembl ID		ENSG00000154589	ENSG00000148346
Uniprot IDs		Q9Y6Y9	P80188
PDB IDs		2E56 2E59 2Z65 3FXI 3ULA 4G8A 8WO1 8WTA	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA 6Z2C 6Z6Z 8UYN 8UZ9
GO Terms Enriched among Interactors		Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Type II Interferon Lipopolysaccharide Immune Receptor Activity Positive Regulation Of Gene Expression Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Lipoteichoic Acid Response To Type II Interferon Detection Of Molecule Of Bacterial Origin Detection Of Chemical Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Detection Of Biotic Stimulus Response To Peptide Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-12 Production Detection Of Stimulus Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Amyloid-beta Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Defense Response To Bacterium Response To Amyloid-beta B Cell Activation Involved In Immune Response Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Glial Cell Development Regulation Of Interleukin-12 Production Triacyl Lipopeptide Binding Positive Regulation Of Interleukin-8 Production Regulation Of Interferon-beta Production Nitric Oxide Production Involved In Inflammatory Response Response To Molecule Of Bacterial Origin Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication	Regulation Of Release Of Cytochrome C From Mitochondria TRC Complex Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Protein-disulfide Reductase Activity Regulation Of ERAD Pathway Protein Targeting To ER Regulation Of Protein Metabolic Process Proteolysis Response To UV Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Response To UV Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Cellular Response To UV-A Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Cellular Response To Light Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Response To UV-A