PPARGC1B

Description		PPARG coactivator 1 beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Mediator Complex
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Nuclear Estrogen Receptor Binding AF-2 Domain Binding
	Biological Process	Regulation Of DNA-templated Transcription Estrogen Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Energy Homeostasis Positive Regulation Of Cold-induced Thermogenesis
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs		Amiodarone
Diseases
GWAS		Age spots ( 29895819) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) Cutaneous malignant melanoma ( 32341527) Deep white matter hyperintensities ( 32517579) Electrocardiographic traits (multivariate) ( 32602732) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 29895819) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Tanning ( 19340012) Vitiligo ( 27723757)
Interacting Genes		13 interacting genes: AKT1 ESR1 ESRRG HCFC1 HNF4A PPARA SRC THRB ZBTB9 ZFP64 ZNF200 ZNF212 ZNF513
Entrez ID		133522
HPRD ID		10594
Ensembl ID		ENSG00000155846
Uniprot IDs		B7ZM40 Q86YN6
PDB IDs		3SP6 6D0Y
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Zinc Ion Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Regulation Of Primary Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nitric-oxide Synthase Regulator Activity Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Estrogen Response Element Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Regulation Of Fatty Acid Beta-oxidation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Branching Involved In Mammary Gland Duct Morphogenesis Cellular Response To Hormone Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Uterus Development Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Enzyme Binding
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