TH and GAD1

		TH	GAD1
Description		tyrosine hydroxylase	glutamate decarboxylase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Cell Cortex Vesicle Membrane Axon Axon Terminus Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression	L-glutamate Catabolic Process Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process Social Behavior Locomotory Exploration Behavior
Pathways		Catecholamine biosynthesis	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin	Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases		Primary torsion dystonia (PTD)	Cerebral palsy
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)	Menopause (age at onset) ( 26414677)
Interacting Genes		22 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI PIAS2 PRKACA PUF60 RBMY1A1 RPS6KA5 SNCA TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	18 interacting genes: AGTRAP BASP1 CALM1 CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE SNCA STK3 TRIM23 TRIP6
Entrez ID		7054	2571
HPRD ID		01865	12011
Ensembl ID		ENSG00000180176	ENSG00000128683
Uniprot IDs		P07101 P78428	A0A0S2Z3V5 Q8IVA8 Q99259
PDB IDs		2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM	2OKJ 3VP6
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytoskeleton Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Sequestering Of Calcium Ion Tau Protein Binding Regulation Of Calcium Ion Transmembrane Transport Response To Metal Ion Dopamine Biosynthetic Process Regulation Of Microtubule Polymerization Enzyme Activator Activity Cellular Response To Epinephrine Stimulus Regulation Of Calcium Ion Transport Vascular Endothelial Cell Response To Fluid Shear Stress Response To Epinephrine Synaptic Transmission, Dopaminergic Regulation Of Monoatomic Cation Transmembrane Transport Cytosol Keratin Filament Regulation Of Microtubule Polymerization Or Depolymerization FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Response To Lead Ion Catecholamine Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Ferrous Iron Binding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Chemical Synaptic Transmission Negative Regulation Of ATP Metabolic Process Calcium Channel Complex Phosphate-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Dopamine Metabolic Process Positive Regulation Of Synaptic Transmission Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Response To Fluid Shear Stress Cell Communication Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Spindle Pole L-amino Acid Metabolic Process Intermediate Filament Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Aromatic Amino Acid Metabolic Process Presynaptic Endocytosis
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