TH and UMAD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TH	UMAD1
Description		tyrosine hydroxylase	UBAP1-MVB12-associated (UMA) domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression
Pathways		Catecholamine biosynthesis
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases		Primary torsion dystonia (PTD)
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)	Coffee consumption ( 31046077) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 28552196) Interstitial lung diseases in rheumatoid arthritis ( 32737115) Intraocular pressure ( 30591961) Small cell lung carcinoma ( 28604730)
Interacting Genes		22 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI PIAS2 PRKACA PUF60 RBMY1A1 RPS6KA5 SNCA TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	2 interacting genes: GABARAPL1 TH
Entrez ID		7054	729852
HPRD ID		01865
Ensembl ID		ENSG00000180176	ENSG00000219545
Uniprot IDs		P07101 P78428	C9J7I0
PDB IDs		2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus	Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Hyaloid Vascular Plexus Regression Synaptic Transmission, Dopaminergic Mating Behavior Serotonin Metabolic Process Melanosome Membrane Catecholamine Biosynthetic Process Anatomical Structure Regression Norepinephrine Biosynthetic Process Smooth Endoplasmic Reticulum Dopamine Biosynthetic Process Cytoplasmic Vesicle Norepinephrine Metabolic Process Embryonic Camera-type Eye Morphogenesis Tyrosine Metabolic Process Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation GABA Receptor Binding Tat Protein Binding Glycogen Catabolic Process Glycophagy Polysaccharide Catabolic Process Embryonic Eye Morphogenesis Amine Biosynthetic Process Eating Behavior Eye Photoreceptor Cell Development Biogenic Amine Biosynthetic Process Reproductive Behavior Dopamine Metabolic Process Aromatic Amino Acid Metabolic Process Photoreceptor Cell Development Beta-tubulin Binding Catecholamine Metabolic Process Pigmentation Autophagosome Maturation Autophagosome Membrane Heart Morphogenesis Mitophagy Eye Morphogenesis Glycogen Metabolic Process Monooxygenase Activity Biogenic Amine Metabolic Process Sensory Organ Morphogenesis Energy Reserve Metabolic Process Polysaccharide Metabolic Process
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