TH and CAMK2G

Number of citations of the paper that reports this interaction (PMID 11359875)
13

Data Source:
HPRD (in vitro)

		TH	CAMK2G
Gene Name		tyrosine hydroxylase	calcium/calmodulin-dependent protein kinase II gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon	Nucleoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Organ Morphogenesis Response To Zinc Ion Multicellular Organismal Aging Response To Activity Synaptic Vesicle Amine Transport Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Cellular Nitrogen Compound Metabolic Process Social Behavior Cellular Response To Drug Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Small Molecule Metabolic Process Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Oxidation-reduction Process Cellular Response To Manganese Ion Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus	G1/S Transition Of Mitotic Cell Cycle Calcium Ion Transport Synaptic Transmission Nervous System Development Regulation Of Skeletal Muscle Adaptation Dephosphorylation Cytokine-mediated Signaling Pathway Insulin Secretion Cell Differentiation Cellular Response To Heat Protein Autophosphorylation Protein Oligomerization Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Relaxation Of Cardiac Muscle
Pathways		Amine-derived hormones Catecholamine biosynthesis Metabolism of amino acids and derivatives	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Phenylalanine L-Tyrosine Tetrahydrobiopterin Metyrosine Meta-Tyrosine 7,8-Dihydrobiopterin
Diseases
GWAS		Prostate cancer ( 19767753)
Protein-Protein Interactions		12 interactors: CAMK2G CDK11B CSNK2A1 MAPK1 MAPK3 MAPKAPK2 PRKACA RPS6KA5 SNCA TYSND1 YWHAB YWHAZ	31 interactors: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CHAT CREM EGFR FLNA GRIA1 GRIA4 GRIN1 GRIN2B LRRC7 MYLK PEA15 PLCB3 PPM1F RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 SYN1 TH TIAM1
Entrez ID		7054	818
HPRD ID		01865	03672
Ensembl ID		ENSG00000180176	ENSG00000148660
Uniprot IDs		P07101 P78428 Q0PWM2 Q0PWM3	Q13280 Q13555 Q5SWX3
PDB IDs		2XSN	2UX0 2V7O
Enriched GO Terms of Interacting Partners?		Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Innate Immune Response Immune Response Phosphate-containing Compound Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Heat Defense Response Apoptotic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Cell Death Death Epidermal Growth Factor Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway ERBB Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Cytokine Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Heat MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Toll-like Receptor 3 Signaling Pathway Regulation Of Intracellular Transport Protein Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity MAPK Cascade Positive Regulation Of Phosphorylation Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Immune System Process Response To Interleukin-1 Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Transferase Activity Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor Signaling Pathway	Signaling Cell Communication Synaptic Transmission Cellular Response To Stimulus Cell-cell Signaling Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Neuron-neuron Synaptic Transmission Signal Transduction Response To Growth Factor Response To Abiotic Stimulus Response To Organic Substance SMAD Protein Complex Assembly Cell Development Intracellular Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Cellular Process Response To Organonitrogen Compound Cell Differentiation Cell Projection Organization Regulation Of Signaling Glutamate Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway System Development Multicellular Organismal Development Neuron Development Regulation Of Synaptic Transmission Platelet Degranulation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Secretion By Cell Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Movement Response To Stress Mesenchyme Development Organ Development Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Import Into Nucleus Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Neurotrophin Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Response To Amphetamine
Tagcloud ?		adrenal avian becomes catecholamine catecholaminergic chromaffin coexpressed coexpression differs embryo galanin ganglia ganglion hydroxylase immunocytochemistry immunoreactivities immunoreactivity intensely neuroactive paravertebral primordia principal repertoire sif somatostatin substances sympathetic sympathoadrenal sympathoblasts synthesizing	agouti cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		adrenal avian becomes catecholamine catecholaminergic chromaffin coexpressed coexpression differs embryo galanin ganglia ganglion hydroxylase immunocytochemistry immunoreactivities immunoreactivity intensely neuroactive paravertebral primordia principal repertoire sif somatostatin substances sympathetic sympathoadrenal sympathoblasts synthesizing	agouti cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?