FMOD and TGFB3

Number of citations of the paper that reports this interaction (PubMedID 8093006)
50

Data Source:
HPRD (in vitro)

		FMOD	TGFB3
Description		fibromodulin	transforming growth factor beta 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Compression Resistance	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transforming Growth Factor Beta Binding
	Biological Process	Transforming Growth Factor Beta Receptor Complex Assembly Collagen Fibril Organization	Response To Hypoxia In Utero Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Positive Regulation Of Protein Secretion Positive Regulation Of Cellular Component Organization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Platelet degranulation Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs			1,4-Dioxane
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Allograft rejection Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Blood protein levels ( 30072576) Obesity-related traits ( 23251661)	Height ( 33713608)
Interacting Genes		5 interacting genes: CFTR FBXO7 TGFB1 TGFB2 TGFB3	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		2331	7043
HPRD ID		02591	01829
Ensembl ID		ENSG00000122176	ENSG00000119699
Uniprot IDs		A0A024R971 B3KS64 Q06828 Q12833	A5YM40 B3KVH9 P10600
PDB IDs		5MX0	1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9 8V52 8VS6 8VSB 9B9F 9FK5
Enriched GO Terms of Interacting Partners?		Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Odontogenesis Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Protein Secretion Gland Morphogenesis Face Morphogenesis Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Uterine Wall Breakdown Regulation Of Macrophage Cytokine Production Response To Ketone Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Protein Transport Regulation Of Protein Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Epithelial To Mesenchymal Transition Platelet Alpha Granule Lumen Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of SMAD Protein Signal Transduction Regulation Of Enamel Mineralization Positive Regulation Of Cell Division Regulation Of Protein Transport Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Type I Transforming Growth Factor Beta Receptor Binding Regulation Of Cytokine Production Involved In Immune Response Animal Organ Morphogenesis Regulation Of Establishment Of Protein Localization Negative Regulation Of Immune System Process Secondary Palate Development Regulation Of Secretion By Cell Positive Regulation Of Cardiocyte Differentiation Growth Factor Activity Regulation Of Secretion Regulation Of Cell Division Cell-cell Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Collagen Biosynthetic Process Cytokine Activity Regulation Of Extracellular Matrix Disassembly Response To Steroid Hormone	Transforming Growth Factor Beta Binding Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Mesenchymal Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Artery Morphogenesis Endocardial Cushion Morphogenesis Heart Trabecula Morphogenesis Regulation Of Cartilage Development Cardiac Septum Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Morphogenesis Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Cell Migration Negative Regulation Of Epithelial Cell Proliferation Regulation Of Chondrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Activity Cardiac Muscle Tissue Morphogenesis Secondary Palate Development Regulation Of Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Ventricular Trabecula Myocardium Morphogenesis Cell Surface Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Muscle Tissue Morphogenesis Wound Healing Tissue Morphogenesis Response To Wounding Roof Of Mouth Development Tissue Development Glycosaminoglycan Binding
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