FMOD

Gene Name		fibromodulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function
	Biological Process	Carbohydrate Metabolic Process Transforming Growth Factor Beta Receptor Complex Assembly Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		3 interactors: TGFB1 TGFB2 TGFB3
Entrez ID		2331
HPRD ID		02591
Ensembl ID		ENSG00000122176
Uniprot IDs		B3KS64 Q06828 Q12833
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macrophage Cytokine Production SMAD Protein Import Into Nucleus Positive Regulation Of Epithelial To Mesenchymal Transition Face Morphogenesis Head Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Salivary Gland Development Uterine Wall Breakdown Response To Progesterone Face Development Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Exocrine System Development Body Morphogenesis Platelet Degranulation Regulation Of Cytokine Production Involved In Immune Response Ossification Involved In Bone Remodeling Positive Regulation Of Ossification Frontal Suture Morphogenesis Tissue Remodeling Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cell Division Negative Regulation Of Immune Response Digestive Tract Development Transforming Growth Factor Beta Receptor Signaling Pathway Cell Growth Digestive System Development Protein Import Gland Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Positive Regulation Of Protein Secretion Regulation Of Ossification Negative Regulation Of Cytokine Production Cell-cell Junction Organization Cranial Suture Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Division Regulation Of SMAD Protein Import Into Nucleus Craniofacial Suture Morphogenesis Response To Laminar Fluid Shear Stress
Tagcloud ?		adenovirus albuminuria assisted clue cytoskeleton desorption diabetic dn exploring fibromodulin flight injections intraperitoneal ionization kidneys killed leucine maldi modulator nephropathy proteoglycan rad rad5 separated spots streptozotocin stz tof vectors