TGFB1 and LAMB1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		TGFB1	LAMB1
Gene Name		transforming growth factor, beta 1	laminin, beta 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Axon Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Extracellular Matrix Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Enzyme Binding Glycosphingolipid Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Ureteric Bud Development Response To Hypoxia Epithelial To Mesenchymal Transition Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Sodium Ion Transport Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Platelet Degranulation Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Response To Radiation Response To Wounding Response To Glucose Defense Response To Fungus, Incompatible Interaction Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Modulation By Virus Of Host Morphology Or Physiology Evasion Or Tolerance Of Host Defenses By Virus Viral Life Cycle Negative Regulation Of Cell-cell Adhesion Platelet Activation Extracellular Matrix Organization Hyaluronan Catabolic Process Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Organ Regeneration Positive Regulation Of Protein Complex Assembly Positive Regulation Of Exit From Mitosis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin D Response To Laminar Fluid Shear Stress Positive Regulation Of Histone Acetylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Odontogenesis Response To Drug Myelination Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Regulatory T Cell Differentiation Cell-cell Junction Organization Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Active Induction Of Host Immune Response By Virus Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Inner Ear Development Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Phagocytosis Positive Regulation Of Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Binding Regulation Of DNA Binding Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Lens Fiber Cell Differentiation Response To Cholesterol Positive Regulation Of Cell Cycle Arrest Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding	Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Embryo Implantation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Epithelial Cell Proliferation
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation TGF-beta receptor signaling activates SMADs Host Interactions with Influenza Factors TGFBR1 LBD Mutants in Cancer Influenza Virus Induced Apoptosis Molecules associated with elastic fibres ECM proteoglycans Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Non-integrin membrane-ECM interactions Influenza Infection Loss of Function of TGFBR1 in Cancer Syndecan interactions Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer	Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions Degradation of the extracellular matrix
Drugs		Hyaluronidase
Diseases
GWAS			IgG glycosylation ( 23382691) Ulcerative colitis ( 19915572 20228799 19122664)
Protein-Protein Interactions		39 interactors: ACVRL1 APP BGN BMP2 BMP3 CCDC33 CCL3 COL2A1 CTGF DAXX DCN DPT EIF3I ENG FCN1 FKBP1A FMOD FNTA ITGAV ITGB6 ITGB8 LAMB1 LTBP1 LTBP3 LTBP4 MEOX2 MMP2 MMP9 PZP SDC2 SPARC TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 VASN VTN YWHAE	10 interactors: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A COL6A1 EIF3I ERBB2IP GFI1B TGFB1
Entrez ID		7040	3912
HPRD ID		01821	01029
Ensembl ID			ENSG00000091136
Uniprot IDs		P01137	P07942 Q8TAS6
PDB IDs		1KLA 1KLC 1KLD 3KFD
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cell Surface Receptor Signaling Pathway Skeletal System Development Cardiovascular System Development Tissue Development Regulation Of Locomotion Multicellular Organismal Development Regulation Of Cellular Component Movement Anatomical Structure Formation Involved In Morphogenesis Locomotion Regulation Of Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Cellular Response To Organic Substance Regulation Of Cell Motility Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Blood Vessel Development Response To Organic Substance Vasculature Development Response To Stimulus Response To Abiotic Stimulus Organ Development Developmental Process System Development Cellular Response To Stimulus Angiogenesis Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Signal Transduction Positive Regulation Of Locomotion Organ Morphogenesis Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding	Cell Growth Neurotransmitter Metabolic Process Ossification Cellular Component Assembly Regulation Of Protein Secretion Cerebellar Molecular Layer Development Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Synapse Assembly Receptor Metabolic Process Endoderm Development Cell Adhesion Growth Acetylcholine Catabolic Process Vestibular Nucleus Development Basal Protein Localization Active Induction Of Host Immune Response By Virus Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Histone Modification Negative Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Neurotransmitter Levels Osteoblast Differentiation Regulation Of Protein Transport Regulation Of Secretion Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Gamma-aminobutyric Acid Secretion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization ERBB Signaling Pathway Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Receptor Biosynthetic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Acetylcholine Secretion, Neurotransmission Synapse Organization Cell Morphogenesis Involved In Differentiation
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	acad amp analogs boylan chambon cyclic dhss dhss2 dnase electrophoretic endoderm enhancer f9 flanking gudas homeobox hypersensitive laminin lohnes maximally natl parietal proc ra taneja teratocarcinoma transcriptionally transfections ttattaaca
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	acad amp analogs boylan chambon cyclic dhss dhss2 dnase electrophoretic endoderm enhancer f9 flanking gudas homeobox hypersensitive laminin lohnes maximally natl parietal proc ra taneja teratocarcinoma transcriptionally transfections ttattaaca
Tagcloud (Intersection) ?