LAMB1 and ACHE

Number of citations of the paper that reports this interaction (PubMedID 15474030)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		LAMB1	ACHE
Description		laminin subunit beta 1	acetylcholinesterase (Yt blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix Laminin Complex Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Basement Membrane Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Neuromuscular Junction Synaptic Cleft Synapse Perinuclear Region Of Cytoplasm Side Of Membrane
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Enzyme Binding Glycosphingolipid Binding	Amyloid-beta Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Identical Protein Binding Protein Homodimerization Activity Laminin Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Embryo Implantation Anatomical Structure Morphogenesis Cell Migration Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Muscle Cell Differentiation Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development Acetylcholine Catabolic Process Cell Adhesion Nervous System Development Synapse Assembly Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Amyloid Precursor Protein Metabolic Process Positive Regulation Of Protein Secretion Retina Development In Camera-type Eye Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
Drugs		Lanoteplase	Choline Tacrine Dipivefrin Gallamine triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Ranitidine Ethanol Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Neostigmine Monoisopropylphosphorylserine Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium Methylphosphinate Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium beta-L-fucose Huperzine B M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene N-acetyl-alpha-D-glucosamine 2-(N-morpholino)ethanesulfonic acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine NAP-226-90 (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM Zanapezil Huperzine A Phenserine Itopride Ganstigmine Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate Methylthioninium Diethylene glycol diethyl ether 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM Dimetacrine Terpinen-4-ol Tyrothricin Choline salicylate
Diseases
GWAS		A body shape index ( 34021172) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Latent naming speed ( 30995994) Pneumoconiosis in silica exposure ( 24986923) Rapid alternating stimulus test for letters/numbers ( 30995994) Rapid automised naming and rapid alternating stimulus test performance ( 30995994) Rapid automised naming of letters ( 30995994) Ulcerative colitis ( 19122664 19915572 20228799 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756) Body mass index ( 29273807) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Type 2 diabetes ( 21490949)
Interacting Genes		15 interacting genes: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A CD79A COL6A1 DYRK1A ERBIN GFI1B GPR152 LMNA PSMC5 UBC UBQLN1	8 interacting genes: APP COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		3912	43
HPRD ID		01029	00010
Ensembl ID		ENSG00000091136	ENSG00000087085
Uniprot IDs		A0A7I2V2T9 A0A7I2V5R0 P07942 Q8TAS6	P22303
PDB IDs		5XAU 7CEC 8DMK	1B41 1F8U 1VZJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA 5HQ3 6CQT 6CQU 6CQV 6CQW 6CQX 6CQY 6CQZ 6F25 6NEA 6NTG 6NTH 6NTK 6NTL 6NTM 6NTN 6NTO 6O4W 6O4X 6O50 6O52 6O5R 6O5S 6O5V 6O66 6O69 6U34 6U37 6U3P 6WUV 6WUY 6WUZ 6WV1 6WVC 6WVO 6WVP 6WVQ 6ZWE 7D9O 7D9P 7D9Q 7E3D 7E3H 7RB5 7RB6 7RB7 7XN1 8AEN 8AEV 8DT2 8DT4 8DT5 8DT7
Enriched GO Terms of Interacting Partners?			Basement Membrane Extracellular Matrix Structural Constituent Laminin-1 Complex Laminin Complex Retinal Blood Vessel Morphogenesis Glycosphingolipid Binding Regulation Of Basement Membrane Organization Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Integrin-mediated Signaling Pathway Extracellular Matrix Regulation Of Integrin-mediated Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Glial Cell Development Endoplasmic Reticulum Lumen Cyclin D2-CDK6 Complex Morphogenesis Of An Epithelium Tube Morphogenesis Laminin-8 Complex Regulation Of Extracellular Matrix Organization Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Embryonic Heart Tube Formation Collagen Trimer Positive Regulation Of Muscle Cell Differentiation Acetylcholine Receptor Activator Activity PTB Domain Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Tissue Morphogenesis
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