LAMB1 and ACHE

Number of citations of the paper that reports this interaction (PMID 15474030)
6

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		LAMB1	ACHE
Gene Name		laminin, beta 1	acetylcholinesterase (Yt blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Extracellular Matrix Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Basal Lamina Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Anchored Component Of Membrane Neuromuscular Junction Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Enzyme Binding Glycosphingolipid Binding	Beta-amyloid Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Embryo Implantation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Epithelial Cell Proliferation	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development DNA Replication Acetylcholine Catabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Synaptic Transmission Nervous System Development Synapse Assembly Muscle Organ Development Cell Proliferation Response To Wounding Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Small Molecule Metabolic Process Neurotransmitter Receptor Biosynthetic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Secretion Protein Tetramerization Retina Development In Camera-type Eye
Pathways		Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions Degradation of the extracellular matrix	Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses
Drugs			Choline Tacrine Gallamine Triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Ephedrine Neostigmine Monoisopropylphosphorylserine Huperaine A Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium Methylphosphonic Acid Ester Group Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose 2-(N-Morpholino)-Ethanesulfonic Acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
Diseases
GWAS		IgG glycosylation ( 23382691) Ulcerative colitis ( 19915572 20228799 19122664)	Heart rate ( 23583979) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 21490949)
Protein-Protein Interactions		10 interactors: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A COL6A1 EIF3I ERBB2IP GFI1B TGFB1	9 interactors: APP COL1A1 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		3912	43
HPRD ID		01029	00010
Ensembl ID		ENSG00000091136	ENSG00000087085
Uniprot IDs		P07942 Q8TAS6	P22303
PDB IDs			1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8
Enriched GO Terms of Interacting Partners?		Cell Growth Neurotransmitter Metabolic Process Ossification Cellular Component Assembly Regulation Of Protein Secretion Cerebellar Molecular Layer Development Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Synapse Assembly Receptor Metabolic Process Endoderm Development Cell Adhesion Growth Acetylcholine Catabolic Process Vestibular Nucleus Development Basal Protein Localization Active Induction Of Host Immune Response By Virus Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Histone Modification Negative Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Neurotransmitter Levels Osteoblast Differentiation Regulation Of Protein Transport Regulation Of Secretion Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Gamma-aminobutyric Acid Secretion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization ERBB Signaling Pathway Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Receptor Biosynthetic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Acetylcholine Secretion, Neurotransmission Synapse Organization Cell Morphogenesis Involved In Differentiation	Extracellular Matrix Organization Extracellular Structure Organization Retinal Blood Vessel Morphogenesis Extracellular Matrix Disassembly Axon Guidance Retina Vasculature Morphogenesis In Camera-type Eye Neurotransmitter Catabolic Process Odontogenesis Blood Vessel Development Axonogenesis Vasculature Development Retina Vasculature Development In Camera-type Eye Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Chemotaxis Neurotransmitter Metabolic Process Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Head Development Neuron Projection Development Cell Projection Morphogenesis Neuromuscular Junction Development Cell Part Morphogenesis Cardiovascular System Development Tissue Development Cellular Response To Amino Acid Stimulus Organ Development Response To External Stimulus Collagen Catabolic Process Neuron Development Epithelial Tube Morphogenesis Organ Morphogenesis Embryonic Heart Tube Formation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Cellular Response To Fluoride Collagen Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Blood Vessel Morphogenesis Tube Morphogenesis Cell Differentiation Multicellular Organismal Metabolic Process Neuron Differentiation Cell Projection Organization Morphogenesis Of An Epithelium
Tagcloud ?		acad amp analogs boylan chambon cyclic dhss dhss2 dnase electrophoretic endoderm enhancer f9 flanking gudas homeobox hypersensitive laminin lohnes maximally natl parietal proc ra taneja teratocarcinoma transcriptionally transfections ttattaaca	acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening
Tagcloud (Difference) ?		acad amp analogs boylan chambon cyclic dhss dhss2 dnase electrophoretic endoderm enhancer f9 flanking gudas homeobox hypersensitive laminin lohnes maximally natl parietal proc ra taneja teratocarcinoma transcriptionally transfections ttattaaca	acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening
Tagcloud (Intersection) ?