TFDP1 and E2F6

Number of citations of the paper that reports this interaction (PMID 9501179)
54

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vivo, in vitro)

		TFDP1	E2F6
Gene Name		transcription factor Dp-1	E2F transcription factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleus Transcription Factor Complex MLL1 Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Epidermis Development Gene Expression Anoikis Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of DNA Biosynthetic Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		Loss of Function of TGFBR2 in Cancer Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer Activation of BH3-only proteins Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Pre-NOTCH Transcription and Translation G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer G0 and Early G1 TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		16 interactors: CDK1 CDK2 CDK6 CREBBP E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 SERTAD2 SIAH1 SOCS3 TP53 TP53BP1	14 interactors: APP ARAF BMI1 E2F1 EPC1 EZH1 EZH2 KRTAP10-7 PCGF6 RING1 RYBP TFDP1 TFDP2 ZMYND11
Entrez ID		7027	1876
HPRD ID		01792	04251
Ensembl ID		ENSG00000198176	ENSG00000169016
Uniprot IDs		B4DLQ9 F5H452 Q14186	G5E936 O75461 Q53YM3 Q6Q9Z5 Q6Q9Z6
PDB IDs		2AZE
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Positive Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Cycle Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Lens Fiber Cell Apoptotic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator RNA Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Cell Cycle Checkpoint Regulation Of Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitotic DNA Damage Checkpoint Cell Surface Receptor Signaling Pathway Regulation Of Fibroblast Proliferation	Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Modification Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Histone Ubiquitination Notch Signaling Pathway Biosynthetic Process Anoikis Peptidyl-lysine Modification Histone H3-K27 Methylation Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone Monoubiquitination Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic
Tagcloud ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr rbl1 screen silico sub suitable suv39h1 transcriptomics vital worldwide	193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways
Tagcloud (Difference) ?		accounts adenocarcinoma applicable assist deaths diagnostics effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr rbl1 screen silico sub suitable suv39h1 transcriptomics vital worldwide	193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways
Tagcloud (Intersection) ?		e2f6