TFDP1 and E2F4

Number of citations of the paper that reports this interaction (PubMedID 36652389)
40

Data Source:
BioGRID (affinity chromatography technology, cross-linking study)
HPRD (in vitro)

		TFDP1	E2F4
Description		transcription factor Dp-1	E2F transcription factor 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Epidermis Development Anoikis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Negative Regulation Of Fat Cell Proliferation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process	Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis Blood Circulation Regulation Of Cell Size Animal Organ Morphogenesis Cell Projection Organization Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria G0 and Early G1 Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Height ( 31562340) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mild influenza (H1N1) infection ( 26379185)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		20 interacting genes: CDK1 CDK2 CDK6 CDKN2A CREBBP CRYAA E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 OGT SERTAD2 SIAH1 SOCS3 TP53 TP53BP1 UBC	34 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RECQL RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRIM33 TRRAP USP2 XPO1
Entrez ID		7027	1874
HPRD ID		01792	02806
Ensembl ID		ENSG00000198176	ENSG00000205250
Uniprot IDs		Q14186	Q16254
PDB IDs		2AZE 5GOW 5TUU 5TUV	1CF7 5TUU
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage P53 Binding Regulation Of Gene Expression Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cis-regulatory Region Sequence-specific DNA Binding Cell Cycle G1/S Phase Transition Apoptotic Process Cyclin-dependent Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Programmed Cell Death Cell Death DNA-binding Transcription Factor Activity Negative Regulation Of Transcription By RNA Polymerase II Cyclin Binding Lens Fiber Cell Apoptotic Process Regulation Of DNA Replication Intracellular Signal Transduction Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Negative Regulation Of Cell Cycle Process	Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Lipid Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromatin Positive Regulation Of Metabolic Process Co-SMAD Binding Chromatin Organization DNA Binding Regulation Of Cell Cycle Process IkappaB Kinase Activity Paraxial Mesoderm Morphogenesis Promoter-specific Chromatin Binding R-SMAD Binding Cell Differentiation BHLH Transcription Factor Binding Ubiquitin Protein Ligase Binding Mesoderm Morphogenesis Rb-E2F Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle
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