TFDP1 and E2F5

Number of citations of the paper that reports this interaction (PMID 7892279)
91

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro)

		TFDP1	E2F5
Gene Name		transcription factor Dp-1	E2F transcription factor 5, p130-binding
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Epidermis Development Gene Expression Anoikis Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of DNA Biosynthetic Process	Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Gene Expression Cell Projection Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways		Loss of Function of TGFBR2 in Cancer Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer Activation of BH3-only proteins Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Pre-NOTCH Transcription and Translation G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer G0 and Early G1 TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 SMAD4 MH2 Domain Mutants in Cancer	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CDK1 CDK2 CDK6 CREBBP E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 SERTAD2 SIAH1 SOCS3 TP53 TP53BP1	7 interactors: CREBBP EP300 RBL1 RBL2 SMAD3 TFDP1 XPO1
Entrez ID		7027	1875
HPRD ID		01792	02983
Ensembl ID		ENSG00000198176	ENSG00000133740
Uniprot IDs		B4DLQ9 F5H452 Q14186	Q15329
PDB IDs		2AZE
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Positive Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Cycle Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Lens Fiber Cell Apoptotic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator RNA Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Cell Cycle Checkpoint Regulation Of Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitotic DNA Damage Checkpoint Cell Surface Receptor Signaling Pathway Regulation Of Fibroblast Proliferation	Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Viral Process N-terminal Peptidyl-lysine Acetylation Cell Cycle DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Notch Signaling Pathway RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromatin Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Modification Chromatin Organization Regulation Of Cellular Response To Heat Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Organic Substance Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Response To Hypoxia Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr rbl1 screen silico sub suitable suv39h1 transcriptomics vital worldwide	angiogenic anticarcinogenic c33a cascades collapse dr5 e6 e7 extrinsic fadd fasl fitc flavonoid fluorescein hela iodide isothiocyanate luteolin multidrug observing oncogenes papilloma performing prb propidium trail versa vice xl
Tagcloud (Difference) ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr rbl1 screen silico sub suitable suv39h1 transcriptomics vital worldwide	angiogenic anticarcinogenic c33a cascades collapse dr5 e6 e7 extrinsic fadd fasl fitc flavonoid fluorescein hela iodide isothiocyanate luteolin multidrug observing oncogenes papilloma performing prb propidium trail versa vice xl
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