TFDP1 and E2F5

Number of citations of the paper that reports this interaction (PubMedID 7760804)
40

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		TFDP1	E2F5
Description		transcription factor Dp-1	E2F transcription factor 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Epidermis Development Anoikis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Negative Regulation Of Fat Cell Proliferation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Projection Organization Positive Regulation Of DNA-templated Transcription
Pathways		Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria G0 and Early G1 Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Height ( 31562340) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mild influenza (H1N1) infection ( 26379185)	Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)
Interacting Genes		20 interacting genes: CDK1 CDK2 CDK6 CDKN2A CREBBP CRYAA E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 OGT SERTAD2 SIAH1 SOCS3 TP53 TP53BP1 UBC	8 interacting genes: CREBBP DNMT3L EP300 RBL1 RBL2 SMAD3 TFDP1 XPO1
Entrez ID		7027	1875
HPRD ID		01792	02983
Ensembl ID		ENSG00000198176	ENSG00000133740
Uniprot IDs		Q14186	Q15329
PDB IDs		2AZE 5GOW 5TUU 5TUV	5TUV
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage P53 Binding Regulation Of Gene Expression Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cis-regulatory Region Sequence-specific DNA Binding Cell Cycle G1/S Phase Transition Apoptotic Process Cyclin-dependent Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Programmed Cell Death Cell Death DNA-binding Transcription Factor Activity Negative Regulation Of Transcription By RNA Polymerase II Cyclin Binding Lens Fiber Cell Apoptotic Process Regulation Of DNA Replication Intracellular Signal Transduction Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Negative Regulation Of Cell Cycle Process	Transcription Regulator Complex DNA-binding Transcription Factor Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of Lipid Kinase Activity Transcription Coactivator Binding Promoter-specific Chromatin Binding Regulation Of Gene Expression Chromatin DNA Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Protein Localization To Nucleus Peptidyl-lysine Acetylation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cellular Response To Heat Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone Acetyltransferase Complex Regulation Of Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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