HCRTR2 and HCRT

Number of citations of the paper that reports this interaction (PubMedID 9491897)
0

Data Source:
HPRD (in vivo)

		HCRTR2	HCRT
Description		hypocretin receptor 2	hypocretin neuropeptide precursor
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane Synapse	Extracellular Region Endoplasmic Reticulum Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Postsynapse Neuronal Dense Core Vesicle Lumen
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding	Neuropeptide Hormone Activity Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Cellular Response To Hormone Stimulus Locomotion Regulation Of Cytosolic Calcium Ion Concentration	Temperature Homeostasis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Response To Alcohol Positive Regulation Of Cold-induced Thermogenesis
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Suvorexant Lemborexant Daridorexant	Pidolic acid
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Blood urea nitrogen levels ( 31152163) Chronotype ( 27494321 30696823) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Fasting glucose change (long-term) ( 31263163) HIV-1 control ( 20041166) Menarche (age at onset) ( 25231870) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 27494321) Severity of nausea and vomiting of pregnancy ( 29563502) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		2 interacting genes: CD200 HCRT	3 interacting genes: HCRTR1 HCRTR2 NPFFR2
Entrez ID		3062	3060
HPRD ID		08374	03836
Ensembl ID		ENSG00000137252	ENSG00000161610
Uniprot IDs		O43614 S4X0W3	O43612
PDB IDs		4S0V 5WQC 5WS3 6TPG 6TPJ 6TPN 7L1U 7L1V 7SQO 7SR8 7XRR	1CQ0 1R02 1UVQ 1WSO 7L1U
Enriched GO Terms of Interacting Partners?		Regulation Of Secretion Regulation Of Secretion By Cell Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Positive Regulation Of Transmission Of Nerve Impulse Neuronal Dense Core Vesicle Lumen Regulation Of Transport Negative Regulation Of Transmission Of Nerve Impulse Sleep Regulation Of Protein Secretion Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of T Cell Migration Glycosylated Region Protein Binding Negative Regulation Of Matrix Metallopeptidase Secretion Distal Tubule Development Metanephric Nephron Development Ductus Arteriosus Closure Negative Regulation Of Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Protein Transport Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Lymphocyte Migration Regulation Of Establishment Of Protein Localization Negative Regulation Of Macrophage Migration Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Nephron Development Sympathetic Nervous System Development Collecting Duct Development Negative Regulation Of Nervous System Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Smooth Muscle Tissue Development Nephron Tubule Development Negative Regulation Of DNA Replication Negative Regulation Of Metabolic Process Aorta Morphogenesis Renal Tubule Development Neuropeptide Hormone Activity Negative Regulation Of Potassium Ion Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Retina Layer Formation Rough Endoplasmic Reticulum Eating Behavior Temperature Homeostasis Cell-cell Adhesion Mediator Activity Negative Regulation Of Mononuclear Cell Migration Heterotypic Cell-cell Adhesion Hindlimb Morphogenesis	Orexin Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Receptor Activity Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity Peptide Hormone Binding Regulation Of Cytosolic Calcium Ion Concentration Response To Hormone Feeding Behavior G Protein-coupled Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Circadian Sleep/wake Cycle Process Regulation Of Circadian Sleep/wake Cycle, Wakefulness Opioid Receptor Binding Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Cellular Homeostasis Signaling Cell-cell Signaling Regulation Of Circadian Sleep/wake Cycle Circadian Behavior Rhythmic Behavior Cell Communication Regulation Of MAPK Cascade Chemical Homeostasis Synapse Regulation Of Behavior Signal Transduction Homeostatic Process Plasma Membrane Regulation Of Circadian Rhythm Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Detection Of Abiotic Stimulus Circadian Rhythm
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