HCRTR2

Gene Name		hypocretin (orexin) receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Feeding Behavior Circadian Sleep/wake Cycle Process Cellular Response To Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		HIV-1 control ( 20041166)
Protein-protein Interactions		2 interactors: CD200 HCRT
Entrez ID		3062
HPRD ID		08374
Ensembl ID		ENSG00000137252
Uniprot IDs		O43614 S4X0W3
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Neurological System Process Negative Regulation Of Potassium Ion Transport Eating Behavior Negative Regulation Of DNA Replication Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurological System Process Regulation Of Potassium Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Calcium Ion Transport Neuropeptide Signaling Pathway Negative Regulation Of Ion Transport Feeding Behavior Negative Regulation Of DNA Metabolic Process Membrane Depolarization Regulation Of DNA Replication Positive Regulation Of Cytosolic Calcium Ion Concentration
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