SSBP4 and TFAP2B

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		SSBP4	TFAP2B
Gene Name		single stranded DNA binding protein 4	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	Single-stranded DNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Renal Water Homeostasis Glucose Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Lithium Ion Retina Layer Formation Magnesium Ion Homeostasis Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Urine Volume Aorta Morphogenesis Response To Drug Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Regulation Of Insulin Secretion Phosphate Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure Cellular Ammonia Homeostasis Cellular Creatinine Homeostasis Cellular Urea Homeostasis
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Adiposity ( 19557161) Body mass index ( 23563607 20935630) Metabolic syndrome (bivariate traits) ( 21386085) Obesity ( 23563607) Obesity (extreme) ( 21935397) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		5 interactors: IL36RN ISL1 LDB1 LDB2 TFAP2B	11 interactors: CITED1 CITED2 CITED4 HIST1H2AC LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4
Entrez ID		170463	7021
HPRD ID		09579	03360
Ensembl ID		ENSG00000130511	ENSG00000008196
Uniprot IDs		Q9BWG4 Q9BWW5	Q92481
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Structure Maintenance Skin Development Stem Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Regulation Of Protein Secretion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Maintenance Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interferon-gamma Production Tissue Development Hair Follicle Development Hair Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Regulation Of Interleukin-6 Production Regulation Of Secretion Hair Cycle Histone H3-K4 Acetylation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Negative Regulation Of Interferon-gamma Secretion Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Differentiation Regulation Of Protein Localization Stem Cell Maintenance Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Antifungal Humoral Response Positive Regulation Of Hemoglobin Biosynthetic Process Ammonia Homeostasis Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Apoptotic Process Tissue Homeostasis Regulation Of Macrophage Colony-stimulating Factor Production Peripheral Nervous System Neuron Axonogenesis Visceral Motor Neuron Differentiation Urea Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Insulin Secretion Negative Regulation Of Neuron Death Regulation Of Cellular Localization Sensory System Development Negative Regulation Of Protein Homodimerization Activity Cardiac Cell Fate Determination	Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Organ Morphogenesis Response To Estrogen Positive Regulation Of Transcription, DNA-templated Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Response To Interleukin-11 Positive Regulation Of SUMO Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of Transcription, DNA-templated Kidney Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Cortex Formation Fibroblast Apoptotic Process Response To Steroid Hormone Axis Specification Regulation Of Gene Expression Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Mesonephros Development Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Interleukin-9 Transcription, DNA-templated Negative Regulation Of Gene Expression Nephron Development Negative Regulation Of Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia RNA Biosynthetic Process Kidney Epithelium Development Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Cellular Metabolic Process Determination Of Left/right Asymmetry In Lateral Mesoderm
Tagcloud ?			438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Difference) ?			438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Intersection) ?