SSBP4 and IL36RN

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		SSBP4	IL36RN
Gene Name		single stranded DNA binding protein 4	interleukin 36 receptor antagonist
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Space
	Molecular Function	Single-stranded DNA Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity
	Biological Process		Negative Regulation Of Cytokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Antifungal Humoral Response Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Negative Regulation Of Interferon-gamma Secretion
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		5 interactors: IL36RN ISL1 LDB1 LDB2 TFAP2B	7 interactors: MCM6 REL SKIL SSBP2 SSBP3 SSBP4 ZNF512B
Entrez ID		170463	26525
HPRD ID		09579	16112
Ensembl ID		ENSG00000130511	ENSG00000136695
Uniprot IDs		Q9BWG4 Q9BWW5	Q9UBH0
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Structure Maintenance Skin Development Stem Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Regulation Of Protein Secretion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Maintenance Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interferon-gamma Production Tissue Development Hair Follicle Development Hair Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Regulation Of Interleukin-6 Production Regulation Of Secretion Hair Cycle Histone H3-K4 Acetylation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Negative Regulation Of Interferon-gamma Secretion Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Differentiation Regulation Of Protein Localization Stem Cell Maintenance Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Antifungal Humoral Response Positive Regulation Of Hemoglobin Biosynthetic Process Ammonia Homeostasis Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Apoptotic Process Tissue Homeostasis Regulation Of Macrophage Colony-stimulating Factor Production Peripheral Nervous System Neuron Axonogenesis Visceral Motor Neuron Differentiation Urea Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Insulin Secretion Negative Regulation Of Neuron Death Regulation Of Cellular Localization Sensory System Development Negative Regulation Of Protein Homodimerization Activity Cardiac Cell Fate Determination	Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Anterior Head Development Neural Plate Anterior/posterior Regionalization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Protein Heterotrimerization Midbrain-hindbrain Boundary Development Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication RNA Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Protein Homotrimerization Rostrocaudal Neural Tube Patterning Gene Expression Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors DNA Strand Elongation Involved In DNA Replication Regulation Of Transcription From RNA Polymerase II Promoter DNA Strand Elongation Lens Fiber Cell Differentiation DNA Replication Initiation Protein Trimerization Blastocyst Formation Head Morphogenesis NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Immune System Process Response To Cytokine Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Chordate Embryonic Development Body Morphogenesis
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