ABCB4

Description		ATP binding cassette subfamily B member 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity ABC-type Transporter Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1
Drugs
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels ( 30275531)
Novel Interacting Genes		1 novel interacting genes: PRKAR2B
Interacting Genes		3 interacting genes: HAX1 PIGY TESK1
Entrez ID		5244
HPRD ID		01371
Ensembl ID		ENSG00000005471
Uniprot IDs		P21439
PDB IDs		6S7P 7NIU 7NIV 7NIW
Enriched GO Terms of Interacting Partners?		Response To Antipsychotic Drug Protein Domain Specific Binding CAMP-dependent Protein Kinase Regulator Activity Podocyte Cell Migration Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Actin Filament Organization Lamellipodium Granulocyte Colony-stimulating Factor Signaling Pathway Interleukin-1 Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Granulocyte Differentiation
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