ABCB4 and PIGY

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ABCB4	PIGY
Name		ATP binding cassette subfamily B member 4	phosphatidylinositol glycan anchor biosynthesis class Y
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity ABC-type Transporter Activity	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport	GPI Anchor Biosynthetic Process
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1	Synthesis of glycosylphosphatidylinositol (GPI)
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)	None
GWAS		Alanine aminotransferase levels ( 33547301 33339817 ) Alanine transaminase levels ( 29403010 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Epithelial ovarian cancer ( 25134534 ) Gallbladder cancer ( 28274756 ) Gallstone disease ( 30504769 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean reticulocyte volume ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Total cholesterol levels ( 30275531 )	Bipolar disorder ( 22925353 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Novel Interactors		1 novel interactors: PRKAR2B	None recorded
Interacting Genes		3 interacting genes: HAX1 PIGY TESK1	5 interacting genes: ABCB4 ERG28 FBXO7 PIGA TMEM72
Entrez ID		5244	84992
HPRD ID		01371	17492
Ensembl ID		ENSG00000005471	ENSG00000255072
Uniprot IDs		P21439	Q3MUY2
PDB IDs		6S7P 7NIU 7NIV 7NIW	Not available
GO Terms Enriched among Interactors		Response To Antipsychotic Drug Protein Domain Specific Binding CAMP-dependent Protein Kinase Regulator Activity Podocyte Cell Migration Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Actin Filament Organization Lamellipodium Granulocyte Colony-stimulating Factor Signaling Pathway Interleukin-1 Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Granulocyte Differentiation	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Cellular Response To Bile Acid Response To Fenofibrate Ceramide Floppase Activity Ceramide Translocation Lewy Body Core Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Lipid Metabolic Process ATPase-coupled Intramembrane Lipid Transporter Activity Positive Regulation Of Phospholipid Transport Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway