DYNLT3 and PMS1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DYNLT3	PMS1
Name		dynein light chain Tctex-type 3	PMS1 homolog 1, mismatch repair system component
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Mitotic Spindle Astral Microtubule	Nucleus Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Microtubule-based Movement Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cell Division	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus
GWAS		No GWAS studies recorded	Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Ferritin levels ( 25162662 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Lung cancer (SNP x SNP interaction) ( 24325914 ) Obesity-related traits ( 23251661 ) Subcutaneous adipose tissue ( 22589738 )
Novel Interactors		4 novel interactors: CYBB FOS IFITM1 UIMC1	None recorded
Interacting Genes		11 interacting genes: C2orf15 CCL28 CD5 DYNC1I1 DYNC1I2 NIF3L1 PMS1 PVR TESC VDAC1 ZC3H14	4 interacting genes: CDC42 DYNLT3 MLH1 RNF10
Entrez ID		6990	5378
HPRD ID		02249	02597
Ensembl ID		ENSG00000165169	ENSG00000064933
Uniprot IDs		P51808	B4DIH7 B7ZAA0 E9PC40 I6L9H5 P54277 Q3BDU3 Q5XG96
PDB IDs		Not available	2CS1
GO Terms Enriched among Interactors		Dynein Light Chain Binding Dynein Heavy Chain Binding Cytoplasmic Dynein Complex	Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Microtubule-based Process Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Late Recombination Nodule Mismatch Repair Complex Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Mitotic Spindle Astral Microtubule Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Establishment Of Golgi Localization Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Schwann Cell Proliferation Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Golgi Transport Complex Positive Regulation Of Cell Cycle Telomere Localization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Microtubule-based Movement Somatic Hypermutation Of Immunoglobulin Genes Spindle Midzone Assembly Golgi Localization Meiotic Chromosome Segregation