DYNLT3 and CYBB

		DYNLT3	CYBB
Description		dynein light chain Tctex-type 3	cytochrome b-245 beta chain
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Mitotic Spindle Astral Microtubule	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Dendrite Phagocytic Vesicle Membrane Monoatomic Ion Channel Complex Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Phagocytic Vesicle Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Protein Binding Electron Transfer Activity NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Voltage-gated Proton Channel Activity Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor NADPH Binding FAD Binding Superoxide-generating NADPH Oxidase Activity
	Biological Process	Microtubule-based Movement Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cell Division	Superoxide Metabolic Process Monoatomic Ion Transport Defense Response Inflammatory Response Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Superoxide Anion Generation Innate Immune Response Response To Ethanol Respiratory Burst Positive Regulation Of Angiogenesis Hydrogen Peroxide Biosynthetic Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Cellular Response To Hypoxia Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin
Pathways			ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Interacting Genes		11 interacting genes: C2orf15 CCL28 CD5 DYNC1I1 DYNC1I2 NIF3L1 PMS1 PVR TESC VDAC1 ZC3H14	7 interacting genes: ACTG1 CYBA CYBC1 IQGAP1 NCF2 NCF4 RAC1
Entrez ID		6990	1536
HPRD ID		02249	02382
Ensembl ID		ENSG00000165169	ENSG00000165168
Uniprot IDs		P51808	A0A0S2Z3S6 P04839
PDB IDs			3A1F 7U8G 8GZ3 8KEI 8WEJ 8X2L
Enriched GO Terms of Interacting Partners?		Dynein Light Chain Binding Dynein Heavy Chain Binding Cytoplasmic Dynein Complex	Respiratory Burst NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Phagolysosome Actin Filament Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Focal Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Basal Body Patch Regulation Of Focal Adhesion Assembly Regulation Of Endocytosis Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Electron Transfer Activity Regulation Of Cell-substrate Junction Organization Protein Kinase Binding Regulation Of Stress Fiber Assembly Endocytosis Phagocytosis Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Cytoplasmic Ribonucleoprotein Granule Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Secretory Granule Membrane Cerebral Cortex GABAergic Interneuron Development Regulation Of Renal Output By Angiotensin Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of Cell-matrix Adhesion Regulation Of Transepithelial Transport Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamine Regulation Of Reactive Oxygen Species Metabolic Process Response To External Biotic Stimulus Mitotic Spindle Astral Microtubule Actomyosin Contractile Ring Assembly Actin Filament Organization Respiratory Burst After Phagocytosis Dense Body Positive Regulation Of Mucus Secretion Defense Response Import Into Cell Regulation Of Ovarian Follicle Development Erythrocyte Enucleation
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