RPGRIP1L and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 19464661)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)

		RPGRIP1L	TBXA2R
Description		RPGRIP1 like	thromboxane A2 receptor
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Axoneme Nuclear Speck Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Anchoring Junction	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Protein Binding Thromboxane A2 Receptor Binding	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	In Utero Embryonic Development Establishment Of Planar Polarity Kidney Development Liver Development Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Brain Development Regulation Of Smoothened Signaling Pathway Regulation Of Signal Transduction Neural Tube Patterning Telencephalon Development Cerebellum Development Lateral Ventricle Development Olfactory Bulb Development Corpus Callosum Development Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Camera-type Eye Development Nose Development Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Retinal Rod Cell Development Pericardium Development Cilium Assembly Head Development Cochlea Development Non-motile Cilium Assembly	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Hedgehog 'off' state Anchoring of the basal body to the plasma membrane	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs			Ridogrel Seratrodast Morniflumate
Diseases		Joubert syndrome Meckel syndrome (MKS); Meckel-Gruber syndrome COACH syndrome
GWAS		Abdominal subcutaneous adipose tissue volume ( 34128465) Bipolar disorder ( 21254220) Bipolar disorder or body mass index ( 31754094) Body mass index ( 29273807) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Kidney volume ( 34128465) Plasma anti-thyroglobulin levels ( 29678681) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Visceral adipose tissue volume ( 34128465) Weight ( 28552196)
Interacting Genes		1 interacting genes: TBXA2R	35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15
Entrez ID		23322	6915
HPRD ID		17204	01768
Ensembl ID		ENSG00000103494	ENSG00000006638
Uniprot IDs		A0A087WX34 B7ZKJ9 H3BPS4 H3BV03 I3L1B5 Q68CZ1	P21731 Q05C92 Q0VAB0
PDB IDs		2YRB	8XJN 8XJO
Enriched GO Terms of Interacting Partners?		Neurotransmitter:sodium Symporter Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Sodium:chloride Symporter Activity Norepinephrine:sodium Symporter Activity Dopamine:sodium Symporter Activity Response To Xenobiotic Stimulus Norepinephrine Uptake Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Transport Monoamine Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Neurotransmitter Transmembrane Transporter Activity Response To Pain Dopamine Transport Neurotransmitter Reuptake Monoamine Transport Neuronal Cell Body Membrane Neurotransmitter Uptake Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Coagulation Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Positive Regulation Of Blood Pressure Beta-tubulin Binding Response To Testosterone Alpha-tubulin Binding Positive Regulation Of Muscle Contraction Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Smooth Muscle Contraction	Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH
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